Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [Tc]Tc(CO)-(HE)-Ec1 for Visualization of EpCAM-Expressing Lung Cancer.

A high level of EpCAM overexpression in lung cancer makes this protein a promising target for targeted therapy. Radionuclide visualization of EpCAM expression would facilitate the selection of patients potentially benefiting from such treatment. Single-photon computed tomography (SPECT) using Tc-labeled engineered scaffold protein DARPin Ec1 has shown its effectiveness in imaging tumors with overexpression of EpCAM in preclinical studies, providing high contrast just a few hours after injection.

Collagen Membrane as Artificial Dura Substitute: A Comprehensive In Vivo Study of Efficiency and Substitution Compared to Durepair.

Background And Objectives: The dura mater is a barrier between the brain and the surrounding environment. Injuries to the dura can lead to serious complications, therefore, ensuring a hermetic closure of the dura is a primary task for a neurosurgeon. The aim of the study is to compare the effectiveness of applying the newly developed ViscollDURA collagen membrane (VDCM), with the commercially available Durepair (xenogeneic collagen) in animal model.

[Foreign language as an element of professionalism of medical workers].

High-quality medical care and effective public health are impossible without adequate staffing. Modern medicine is subject to the trends of globalization and internationalization, like many other industries and spheres of the national economy, and today both doctors and nurses often provide medical care to foreign-speaking citizens: tourists, migrants, refugees, foreign students, etc. The article provides an overview of publications reflecting the importance of linguistic training and knowledge of foreign languages for medical professionals.

3D printing in pediatric neurosurgery: experimental study of a novel approach using biodegradable materials.

Purpose: 3D printing technologies have become an integral part of modern life, and the most routinely used materials in reconstructive surgery in children are biodegradable materials. The combination of these two technologies opens up new possibilities for the application of innovative methods in neurosurgery and a patient-centered approach in medical care. The aim of the study was to determine whether a physician without specialized programming and printing skills could independently create materials in a clinical setting for the treatment of patients.

Fingerprint Raman spectroscopy for two-dimensional MoSSealloys.

Two-dimensional transition metal dichalcogenides (TMDs) and alloys based on them, is a promising platform for creating opto- and nanoelectronic devices. For layered alloys, there is a strong need to theoretically determine the frequencies of vibrational modes and dependences of their energies on the stoichiometric composition. By comparing experimentally measured Raman modes with theoretical predictions, it becomes possible to determine the stoichiometric composition of the manufactured alloys.