Publications by authors named "E Yu Kryukov"

Article Synopsis
  • - Neuroblastoma (NB) is a serious and complex childhood cancer that can vary widely in its progression; while some tumors may shrink on their own or respond to treatment, about 40% of patients face severe outcomes, especially those in the high-risk category.
  • - Researchers used advanced techniques, like single-cell multi-omics and sequencing, to study human NB and discovered not only adrenergic tumor cells but also unique, aneuploid SCP-like cells that exhibit clonal expansion and specific gene expression patterns.
  • - The study suggests that aneuploid SCP-like cells are a new aspect of NB, indicating that these cells, which may arise from the neural crest lineage, could play a key role in the early
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Parasites have evolved a variety of astonishing strategies to survive within their hosts, yet the most challenging event in their personal chronicles is the passage from one host to another. It becomes even more complex when a parasite needs to pass through the external environment. Therefore, the free-living stages of parasites present a wide range of adaptations for transmission.

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Post-acquisition correction of NMR spectra is an important part of NMR spectroscopy that enables refined NMR spectra to be obtained, clean from undesirable out-phasing, broadening and noising. We describe analytical and numerical mathematical methods for post-acquisition correction of NMR spectra distorted by static and dynamic magnetic field inhomogeneity caused by imperfections of main superconducting coils and the cold head operation, typical for cryogen-free magnets. For the dynamic inhomogeneity, we apply a variant of the general reference deconvolution method, complemented with our mathematical analysis of spectral parameters.

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We show that the temporal magnetic field distortion generated by the Cold Head operation can be removed and high quality Solid-State Magic Angle Spinning NMR results can be obtained with a cryogen-free magnet. The compact design of the cryogen-free magnets allows for the probe to be inserted either from the bottom (as in most NMR systems) or, more conveniently, from the top. The magnetic field settling time can be made as short as an hour after a field ramp.

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