Automated extracellular volume fraction measurement for diagnosis and prognostication in patients with light-chain cardiac amyloidosis.

Aims: T1 mapping on cardiac magnetic resonance (CMR) imaging is useful for diagnosis and prognostication in patients with light-chain cardiac amyloidosis (AL-CA). We conducted this study to evaluate the performance of T1 mapping parameters, derived from artificial intelligence (AI)-automated segmentation, for detection of cardiac amyloidosis (CA) in patients with left ventricular hypertrophy (LVH) and their prognostic values in patients with AL-CA.

Methods And Results: A total of 300 consecutive patients who underwent CMR for differential diagnosis of LVH were analyzed.

Weight loss and body composition after compounded semaglutide treatment in a real world setting.

Introduction: Clinical trials have shown efficacy of semaglutide for weight loss, but further study is needed in less controlled environments including impacts on body composition.

Materials And Methods: This retrospective study included individuals who participated in a weight management programme at a commercial wellness studio receiving once-weekly compounded semaglutide/cyanocobalamin injections from June 2023 to January 2024. Once-weekly semaglutide/cyanocobalamin injected subcutaneously starting at 0.

USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancer.

The emerging role of ubiquitin-specific peptidase 21 (USP21) in stabilizing Fra-1 (FOSL1) highlights its involvement in promoting colorectal cancer (CRC) metastasis. Additionally, a reciprocal link between EGFR signaling and Fra-1 activation has been identified, mediated through matrix metalloproteinases (MMPs). However, the functional implications of the USP21-EGFR signaling axis in metastatic CRC (mCRC) are not fully understood.

Effect of δ-Ferrite Formation and Self-Tempering Behavior on Mechanical Properties of Type 410 Martensitic Stainless Steel Fabricated via Laser Powder Bed Fusion.

This study explores the formation of δ-ferrite and its self-tempering behavior in the microstructure of Type 410 martensitic stainless steel produced via laser powder bed fusion (L-PBF). The study investigates the correlation between varying energy densities applied during the L-PBF process and the resultant mechanical properties of the as-built specimens. A microstructural analysis shows that with an increase in energy density, the δ-ferrite fraction decreases, while the martensite content increases, leading to changes in tensile strength and elongation.

Longitudinal assessment of serum albumin levels with the risk of coronary artery calcification progression in an asymptomatic population of Korean adults: an observational cohort study.

Objectives: This study evaluated the association between serum albumin levels and coronary artery calcification (CAC) progression in asymptomatic adults without hypoalbuminaemia at baseline.

Design: Observational cohort study.

Setting: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) which is a retrospective, single ethnicity, multicentre and observational registry were analysed.