Publications by authors named "E Yap"
Objectives: Health-Significant Quality of Life Measure (Health-SigQOLM) provides a generic and dynamic assessment of Health-related quality of life (HRQOL). This study aims to assess the HRQOL among healthy and non-healthy participants with varying chronic diseases.
Results: Comparisons between healthy and non-healthy participants revealed statistically significant differences (p < 0.
Article Synopsis
- High-dose glucocorticoid (GC)-based treatments for lupus nephritis are common but can cause significant side effects and are not always fully effective; this study explored the impact of adding voclosporin to a low-dose GC regimen.* -
- Participants were matched from two study groups: those receiving voclosporin with low-dose GCs and mycophenolate mofetil (MMF), and those on high-dose GCs with MMF and intravenous cyclophosphamide (IVC); safety and efficacy were evaluated over 6 months.* -
- Results indicated that the voclosporin group experienced fewer adverse events and achieved better reductions in urine protein levels compared to those receiving high-dose GCs
This study aims to compare the health-related quality of life (HRQOL) between healthcare providers without chronic diseases and participants with chronic diseases presenting with one of the four different primary diagnoses on the health-related quality of life with six domains (HRQ-6D) scale. This is a cross-sectional study to compare the HRQOL between healthcare providers without chronic diseases and participants with chronic diseases. Data collection was performed from May 2022 to May 2023.
View Article and Find Full Text PDFPurpose: Bleeding is an important health outcome of interest in epidemiological studies. We aimed to develop and validate rule-based algorithms to identify (1) major bleeding and (2) all clinically relevant bleeding (CRB) (composite of major and all clinically relevant nonmajor bleeding) within real-world electronic healthcare data.
Methods: We took a random sample (n = 1630) of inpatient admissions to Singapore public healthcare institutions in 2019 and 2020, stratifying by hospital and year.
Article Synopsis
- - Dengue fever is caused by the dengue virus and transmitted through infected female mosquitoes, resulting in around 100 million new cases yearly across over 120 countries, with a significant rise in incidence over the past 40 years.
- - Most people experience mild symptoms, but some can develop severe disease, which may lead to death; immune responses and blood-related issues are key factors in severe cases.
- - This review explores the clinical and biological aspects of blood-related symptoms in dengue, highlights critical gaps in current knowledge and practice, and suggests areas for future research.