[EFFICACY OF RADIOFREQUENCY ABLATION OF AORTORENAL SYMPATHETIC NODES IN PATIENTS IN ARTERIAL HYPERTENSION].

Efficacy of radiofrequency ablation (RFA) of prevertebral sympathetic nodes, concern- ing the arterial pressure lowering in 36 patients, suffering hypertonic disease and coex- istent heart diseases, was analyzed. In 12 mo after RFA a systolic arterial pressure lowering at average throughout the group by (3.24 ± 1.

[Peculiarities of the organism immune response in patients suffering ischemic cardiomyopathy].

Ischemic cardiomyopathy (ICMP) constitutes the organspecific systemic form of autoimmune pathology. Now existing hypotheses of the ICMP pathogenesis trust the multistaged course of the disease with concurrent changes in the cellular and humoral chains of immunity. Among the immune disorders there are interrelated chains, influencing the disease course severity.

Role of nitric oxide in the reaction of arterial vessels to laser irradiation.

Reactivity of arterial vessels in the small intestine mesentery to irradiation with a helium-neon laser before and after NO synthase blockade was studied by means of biomicroscopy. Blood flow velocity and vascular diameter increased under conditions of laser irradiation. During irradiation, arterial vasodilation was inversely related to the initial diameter.

[A PARK8 form of Parkinson's disease: a mutational analysis of the LRRK2 gene in Russian population].

A recently described form of Parkinson's disease - PARK8 - is caused by mutations in the novel LRRK2 gene on chromosome 12q12. The most common mutation in this gene is the substitution G2019S and we studied it for the first time in a large group of Russian Slavonic patients (311 patients) with Parkinson's disease including 295 sporadic and 16 familial cases. The mutation LRRK2-G2019S was identified in 1% of patients examined (3 cases) and was not found in a group of population control.

[Significance of immunological investigations in the studying of various forms of cardiomyopathy].

The data concerning the role of the immune and inflammatory reactions activation in formation of dilatational and hypertrophic cardiomyopathy were presented. The dependence of the humoral-inflammatory disbalance progressing on the processes of the apoptosis and inflammatory cytokins level regulation, determining the immune answer disorder degree in relation with cardiomyopathy form, was established.