Age-related morphological changes of the pubic symphyseal surface: using three-dimensional statistical shape modeling.

Computational analysis of the pubic symphyseal surface is widely used for accurate age estimation, offering quantitative precision through the detection of subtle morphological changes. However, these methods often lack insights into the underlying morphological changes across different age groups. To bridge this gap, the study utilizes statistical shape modeling (SSM), a versatile tool capable of describing diverse morphological variations within populations.

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.

Tau pathology in sporadic Alzheimer's disease (AD) follows a distinct pattern, beginning in the entorhinal cortex (ERC) and spreading to interconnected brain regions. Early-stage tau pathology, characterized by soluble phosphorylated tau, is difficult to study in human brains post-mortem due to rapid dephosphorylation. Rhesus macaques, which naturally develop age-related tau pathology resembling human AD, provide an ideal model for investigating early tau etiology.

Post-Traumatic Longitudinal Atlanto-Occipital Dissociation without Neurodeficits Treated with Visor (Head-Neck-Chest ) Orthosis - a Rare Case Report and Review of the Literature.

Introduction: Death is the most common outcome of longitudinal atlanto-occipital dissociation (L-AOD). Even though rare, survival is commonly seen in the pediatric population. This study reports a successful outcome of a pediatric patient with an L-AOD without neurodeficits, immobilized in a visor (head-neck-chest) orthosis.

The application study of harmonization code in medical device adverse event reporting.

Background: The reporting of adverse events in medical devices (MD) is a starting point of post-market surveillance and the most common source of initial safety signals. Because MD adverse events (AE) occur globally and involve high-profile international public health crises, international regulators implanted standard codes for MDAE reporting. This study aimed to assess the application of MDAE terminology and codes by providing examples of virtual events.

Spatially resolved gene expression profiles of fibrosing interstitial lung diseases.

Fibrosing interstitial lung diseases (ILDs) encompass a diverse range of scarring disorders that lead to progressive lung failure. Previous gene expression profiling studies focused on idiopathic pulmonary fibrosis (IPF) and bulk tissue samples. We employed digital spatial profiling to gain new insights into the spatial resolution of gene expression across distinct lung microenvironments (LMEs) in IPF, chronic hypersensitivity pneumonitis (CHP) and non-specific interstitial pneumonia (NSIP).