Publications by authors named "E Y Plotnikov"
The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, Tc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective Tc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues.
View Article and Find Full Text PDFThe noble gas argon is one of the most promising neuroprotective agents for hypoxic-reperfusion injuries of the brain. However, its effect on traumatic injuries has been insufficiently studied. The aim of this study was to analyze the effect of the triple inhalation of the argon-oxygen mixture Ar 70%/O 30% on physical and neurological recovery and the degree of brain damage after traumatic brain injury and to investigate the possible molecular mechanisms of the neuroprotective effect.
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- * This study developed and characterized iron nanoparticles doped with selenium (FeNP@SeNPs) to explore their effects on the calcium signaling system in astrocytes under ischemia-like conditions.
- * The research found that combining magnetic selenium nanoparticles with electromagnetic stimulation enhances cell penetration and facilitates endocytosis through TRPV4 channel activation, allowing for a reduced effective concentration compared to traditional selenium nanoparticles.
Article Synopsis
- The study focuses on creating new fluorosulfate derivatives of 1,4-naphthoquinone through the SuFEx reaction and evaluates their anticancer effects on various cancer cell lines, showing they are more cytotoxic than Cisplatin.
- The electronic structures of these compounds were analyzed using Density Functional Theory (DFT) to understand their cytotoxic properties.
- A method using an impregnated graphite electrode (IMGE) was developed for detecting these compounds, and their electrochemical behavior was examined using cyclic voltammetry.
We studied the radical-binding and antioxidant activities of the alkaloid tryptanthrin (TR) and its new synthetic derivative tryptanthrin oxime (TR-Ox), as well as the cytoprotective activity of TR-Ox under conditions of oxidative stress. The antiradical activity of TR-Ox was revealed in the test of binding with stable chromogen radical 2,2-diphenyl-1-picrylhydrazyl and in the superoxide radical generation test (riboflavin photoreduction reaction with detection by NBT reduction). TR-Ox was inferior to ionol and dihydroquercetin by the antiradical activity.
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