Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.

Biological datasets often consist of thousands or millions of variables, e.g. genetic variants or biomarkers, and when sample sizes are large it is common to find many associated with an outcome of interest, for example, disease risk in a GWAS, at high levels of statistical significance, but with very small effects.

Structurally Transformable and Reconfigurable Hydrogel-Based Mechanical Metamaterials and Their Application in Biomedical Stents.

Mechanical metamaterials exhibit several unusual mechanical properties, such as a negative Poisson's ratio, which impart additional capabilities to materials. Recently, hydrogels have emerged as exceptional candidates for fabricating mechanical metamaterials that offer enhanced functionality and expanded applications due to their unique responsive characteristics. However, the adaptability of these metamaterials remains constrained and underutilized, as they lack integration of the hydrogels' soft and responsive characteristics with the metamaterial design.

Developing a theory of change to guide the design and implementation of a caregiver-centric support service.

Background: Set against the backdrop of a rapidly ageing population and growing emphasis on the importance of ageing-in-place, family members often assume the role of a caregiver. Navigating through a complex healthcare system while simultaneously juggling the daily care needs of their care-recipients, caregivers often become worn out by the intense caregiver stress and burden, neglecting their own well-being. This translates to adverse health and economic outcomes such as prolonged hospital stays and increased nursing home placement of care-recipients.

Public fertility preservation programme for cancer patients in Hong Kong.

Introduction: Fertility preservation (FP) offers cancer patients the opportunity to have biological children after completing treatment. This study was performed to review the experience and changes in service demand since the implementation of a public FP programme for cancer patients in Hong Kong.

Methods: This retrospective study included men and women who attended an assisted reproduction unit for public FP services before cancer treatment from August 2020 to February 2023.