IFN-γ derived from activated human CD4 T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strain.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit both T cell and B cell immune responses in immunocompetent individuals. However, the mechanisms underlying the antiviral effects mediated by CD4 T cells are not fully understood. In this study, we analyzed the culture supernatant (SN) from polyclonally stimulated human CD4 T cells as a model for soluble mediators derived from SARS-CoV-2-stimulated CD4 T cells.

[Changes in the residence of elderly people after hospitalization in the Integrated Community Care Ward].

Aim: When elderly people return to their daily lives after inpatient treatment, they may be offered a chance to change the residence to which they are accustomed. The present study clarified the changes in the residence of elderly patients through an Integrated Community Care Ward (ICCW).

Subjects And Methods: Patients were admitted to and discharged from the ICCW (53 beds) of Hospital A, located in a city with a population of 30,000 and an aging rate of 37%, for 2 years from April 1, 2018, to March 31, 2020.

Association of oral hypofunction with aspiration pneumonia, fractures, and mortality in older Japanese adults.

Aim: In Japan's public health system, dentists can assess and intervene in oral hypofunction cases. However, the associations between oral hypofunction and health outcomes and costs remain unclear. This study aimed to identify these associations.

Nutritional therapy for reducing disability and improving activities of daily living in people after stroke.

Background: Stroke patients often face disabilities that significantly interfere with their daily lives. Poor nutritional status is a common issue amongst these patients, and malnutrition can severely impact their functional recovery post-stroke. Therefore, nutritional therapy is crucial in managing stroke outcomes.