[Zinc homeostasis and indicators of muscle activity in experimental graduated exercise on the background of zinc asparaginate].

The influence of a regular (for 7 and 14 days) 10-minute dosed exercise in isolation and on the background of intragastric administration of 5 and 15 mg/kg of zinc (II) asparaginate on the distribution of this metal in the organs and tissues of experimental animals and the indicators of muscle activity such as the level of lactate, creatinine and creatine kinase (EC 2.7.3.

Immobilized metal affinity chromatography on collapsed Langmuir-Blodgett iron(III) stearate films and iron(III) oxide nanoparticles for bottom-up phosphoproteomics.

Phosphorylation is the enzymatic reaction of site-specific phosphate transfer from energy-rich donors to the side chains of serine, threonine, tyrosine, and histidine residues in proteins. In living cells, reversible phosphorylation underlies a universal mechanism of intracellular signal transduction. In this context, analysis of the phosphoproteome is a prerequisite to better understand the cellular regulatory networks.

Evaluation of the neurological status in experimental acute alcohol intoxication.

Approaches to evaluation of the severity of neurological disorders in animals with experimental acute severe alcohol intoxication were developed. Using the method of statistical analysis, we selected criteria, which can be used for evaluation of the severity of inhibition of the nervous system in studies of the alcoholism pathogenesis and for improvement of methods for correction of severe intoxication at the preclinical stage of drug efficiency evaluation.

[Acute poisoning with ethylene glycol esters].

The study was performed of 13 acute oral poisonings with ethylene glycol ethers characterized as moderate or severe and resulting in poor outcome in 3 cases. Ethyl ether was responsible for 3 poisonings, methyl ether for 10 ones. It was found, that the intoxication had four stages or periods (initial, latent, clinical, recovery) and presented with CNS impairment, gastrointestinal, hepatic, renal disorders, decompensated metabolic acidosis, etc.