Beneficial Effects of FEC on an In-Situ Polymerized Deep Eutectic Electrolyte for Solid-State Batteries.

Eutectic-based polymer electrolytes have emerged as promising solid electrolytes because of their ionic liquid-like properties, while modifications are essential to further increase their ionic conductivity at room temperature and solve their compatibility with lithium anode. In this work, an in situ polymerized composite electrolyte is modified by the addition of fluoroethylene carbonate (FEC) whose beneficial effect is systematically investigated in different contents. Poly(ethylene glycol) diacrylate (PEGDA), deep eutectic solvent (LiTFSI:-methylacetamide = 1:3), and alumina fiber work as the monomer, solvent, and three-dimensional skeleton, respectively.

Usage of Milan System in Risk Stratification of Submandibular Gland Fine Needle Aspiration Cytology.

Objectives: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) categorizes fine needle aspiration and cytology (FNAC) results into 6 tiers and assigns a risk of malignancy (ROM) to each category. Its utility in submandibular gland lesions remains unclear. Our article aims to study (1) the utility of the MSRSGC in classifying FNAC of submandibular gland masses, (2) describe the demographics and incidence of submandibular gland malignancy in our population, and (3) analyze the accuracy of FNAC in diagnosis of benign and malignant submandibular gland tumors.

Periodontitis Increases Gingival, Serum and Hippocampus β-Amyloid Expressions but Reduces Neurovascular Coupling in Basilar Artery of Rats.

Aim: Neurodegenerative diseases are characterized by early increased beta-amyloid (Aβ) and decreased cerebrovascular reactivity. We investigated Aβ in gingiva, serum or hippocampus and neurovascular reactivity in basilar artery (BA) of periodontitis rats, to test the impact of Aβ on BA vasoreactivity ex vivo.

Materials And Methods: Periodontitis was induced in 32 rats using silk-ligation.

Efficacy and safety of iclepertin (BI 425809) with adjunctive computerized cognitive training in patients with schizophrenia.

Unlabelled: Despite significant patient burden, there are no approved pharmacotherapies to treat symptoms of cognitive impairment associated with schizophrenia (CIAS). This double-blind, placebo-controlled, parallel-group Phase II trial assessed the efficacy and safety of pharmacological augmentation of at-home computerized cognitive training (CCT) with iclepertin (BI 425809, a glycine transporter-1 inhibitor). Participants with schizophrenia (aged 18-50 years) on stable antipsychotic therapy, who were compliant with CCT during the run-in period, were enrolled.

Engineering extracellular vesicles for targeted therapeutics in cardiovascular disease.

Extracellular vesicles (EVs) are nanosized particles secreted by cells that play crucial roles in intercellular communication, especially in the context of cardiovascular diseases (CVDs). These vesicles carry complex cargo, including proteins, lipids, and nucleic acids, that reflects the physiological or pathological state of their cells of origin. Multiomics analysis of cell-derived EVs has provided valuable insights into the molecular mechanisms underlying CVDs by identifying specific proteins and EV-bound targets involved in disease progression.