Publications by authors named "E Wunder"
Article Synopsis
- The research focuses on leptolysin, a metalloproteinase secreted by the bacteria Leptospira, which may aid in the bacteria's ability to cause disease by degrading host immune system components.
- A portion of patients with mild leptospirosis showed antibodies against leptolysin, indicating its expression during infection; experiments with knockout strains demonstrated that leptolysin helps the bacteria resist serum from the host.
- Although a mutant strain lacking leptolysin was still virulent in hamsters, it resulted in lower bacterial levels in the kidneys, suggesting the need for further investigation into the role of metalloproteinases in Leptospira pathogenicity.
Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil.
PLoS Negl Trop Dis
May 2024
Article Synopsis
- Leptospirosis is a disease caused by Leptospira bacteria, and this study focuses on identifying factors linked to seropositivity for two specific serogroups in urban Brazil.
- The research involved a cross-sectional study where blood samples from 2,808 residents in Salvador were analyzed to find associations between seropositivity and various demographic, socioeconomic, and environmental factors.
- Findings revealed age, housing conditions, presence of cats, gender, work exposure, and sewage contact as significant risk factors for seropositivity to the respective serogroups Icterohaemorrhagiae and Cynopteri, highlighting distinct epidemiological patterns.
Unlabelled: Rickettsioses and leptospirosis are infectious diseases that are often underdiagnosed due to a lack of knowledge about their epidemiology, pathophysiology, diagnosis, management, among others.
Objetive: to characterize the seroprevalence and seroincidence of both and agents and determine the risk factors for these outcomes in rural areas of Urabá, Antioquia.
Methods: a secondary data analysis using information on and exposure from a prior prospective study that explored sociocultural and ecological aspects of infection in rural Urabá, Colombia.
Objectives: The objectives of this study were to determine the seroprevalence and risk factors of leptospirosis among slaughterhouse workers in Burkina Faso.
Methods: We performed a cross-sectional survey of slaughterhouse workers from Ouagadougou and Bobo Dioulasso between March and April 2021. Blood was collected by venipuncture and serum samples were tested using enzyme-linked immunosorbent assay and microscopic agglutination test.
Spirochetes cause Lyme disease, leptospirosis, syphilis, and several other human illnesses. Unlike other bacteria, spirochete flagella are enclosed within the periplasmic space where the filaments distort and push the cell body by the action of the flagellar motors. We previously demonstrated that the oral pathogen (Td) and Lyme disease pathogen (Bb) form covalent lysinoalanine (Lal) cross-links between conserved cysteine and lysine residues of the FlgE protein that composes the flagellar hook.
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