A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations.

Somatic missense mutations in histone genes turn these essential proteins into oncohistones, which can drive oncogenesis. Understanding how missense mutations alter histone function is challenging in mammals as mutations occur in a single histone gene. For example, described oncohistone mutations predominantly occur in the histone H3.

Characterization of persons with reported SARS-CoV-2 infection in the Oklahoma City tri-county area: Evidence from the first 12 months of transmission.

Background: To describe characteristics, hospitalization, and death for reported cases of SARS-CoV-2 infection in the Oklahoma City tri-county area.

Methods: We extracted notified cases of SARS-CoV-2 infection for our study area and used descriptive statistics and modeling to examine case characteristics and calculate the odds of hospitalization and death in relation to a range of explanatory variables.

Results: Between March 12th, 2020 and February 28th, 2021, 124,925 cases of SARS-CoV-2 infection were reported from the study region.

A budding yeast model for human disease mutations in the cap subunit of the RNA exosome complex.

RNA exosomopathies, a growing family of diseases, are linked to missense mutations in genes encoding structural subunits of the evolutionarily conserved, 10-subunit exoribonuclease complex, the RNA exosome. This complex consists of a three-subunit cap, a six-subunit, barrel-shaped core, and a catalytic base subunit. While a number of mutations in RNA exosome genes cause pontocerebellar hypoplasia, mutations in the cap subunit gene cause an apparently distinct clinical presentation that has been defined as a novel syndrome SHRF (hort stature, earing loss, etinitis pigmentosa, and distinctive acies).

Fall prevention interventions in primary care to reduce fractures and falls in people aged 70 years and over: the PreFIT three-arm cluster RCT.

Background: Falls and fractures are a major problem.

Objectives: To investigate the clinical effectiveness and cost-effectiveness of alternative falls prevention interventions.

Design: Three-arm, pragmatic, cluster randomised controlled trial with parallel economic analysis.

Low income dynamics and depression over the life course in South Korea.

Objectives: We examined how experiencing low income multiple times is associated with depressive symptoms over the life course to better understand the influence of low income experience on psychological well-being.

Methods: We employed fixed effects models to estimate the association between low income experience and depressive symptoms using data from a longitudinal survey of a representative sample of adults in Korea (N=6,930). We also considered age variations given different perspectives and social circumstances related to different ages and family stages over the life course that potentially modify the association.