A prospective, split-face, randomized, comparative study of safety and 12-month longevity of three formulations of hyaluronic acid dermal filler for treatment of nasolabial folds.

Background: Data regarding several hyaluronic acids (HAs) used identically for facial tissue augmentation have heretofore been unavailable.

Objectives: This prospective, split-face, randomized, two-armed study sought to determine the long-term safety and effectiveness of three HAs (HA-1 (Belotero Basic/Balance), HA-2 (Restylane), and HA-3 (Juvéderm Ultra 3/Juvéderm Ultra Plus XC) in the treatment of nasolabial folds (NLFs).

Methods: Twenty participants in Arm A received HA-1 in one NLF and HA-2 in the other.