Publications by authors named "E Wirth"
Article Synopsis
- Thyroid hormones (TH) are crucial for regulating cell functions and metabolism, with their synthesis in the thyroid gland relying on high levels of hydrogen peroxide (HO) for iodide oxidation.
- The study investigates Retinol Saturase (RetSat), an enzyme that protects cells from oxidative stress, and finds it is highly expressed in the thyroid gland, influencing TH production and metabolism.
- Deleting RetSat in thyroid cells results in changes to hormone levels and thyroid morphology, suggesting that it plays an important role in maintaining TH balance and overall metabolic stability.
Article Synopsis
- There is a growing concern over the health and environmental risks of PFAS, leading to the development of PFAS-free firefighting foams for military and residential use.
- A study evaluated the chronic toxicity of seven PFAS-free foams and one PFAS-containing foam on six aquatic species, assessing impacts on growth, development, reproduction, and survival.
- Results indicated that some PFAS-free foams were as or more toxic than the PFAS-containing foam, highlighting the need for careful selection of these alternatives to reduce environmental harm.
Objective: The objective of this study was to develop and evaluate the feasibility and safety of a novel transaxial surgical approach for the delivery of human induced pluripotent stem cell-derived dopaminergic neuroprogenitor cells (DANPCs) into the putamen nucleus using nonhuman primates and surgical techniques and tools relevant to human clinical translation.
Methods: Nine immunosuppressed, unlesioned adult cynomolgus macaques (4 females, 5 males) received intraputaminal injections of vehicle or DANPCs (0.9 × 105 to 1.
Objective: Hypothyroidism has been proposed as a potential contributor to steatotic liver disease (SLD), but existing data shows conflicting results in euthyroid subjects. Therefore, we investigated the association between thyroid function and intrahepatic lipids (IHLs) during a 36-month randomized controlled trial evaluating a diet known to reduce liver fat.
Design: 502 eligible subjects (aged 50-80 years, ≥1 risk factor for unhealthy aging) were randomly assigned to either follow a diet rich in unsaturated fatty acids, plant protein, and fiber (intervention group, IG), or dietary recommendations of the German Nutrition Society (control group, CG).
Comparison of chemical contaminant measurements using CLAM, POCIS, and silicone band samplers in estuarine mesocosms.
Integr Environ Assess Manag
September 2024
Discrete water samples represent a snapshot of conditions at a particular moment in time and may not represent a true chemical exposure caused by changes in chemical input, tide, flow, and precipitation. Sampling technologies have been engineered to better estimate time-weighted concentrations. In this study, we consider the utility of three integrative sampling platforms: polar organic chemical integrative sampler (POCIS), silicone bands (SBs), and continuous, low-level aquatic monitoring (CLAM).
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