Publications by authors named "E Wilson-Davies"

Since the advent of direct-acting antiviral therapy, the elimination of hepatitis c virus (HCV) as a public health concern is now possible. However, identification of those who remain undiagnosed, and re-engagement of those who are diagnosed but remain untreated, will be essential to achieve this. We examined the extent of HCV infection among individuals undergoing liver function tests (LFT) in primary care.

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Real-Time polymerase chain reaction (qPCR) is the gold standard diagnostic method for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Cycle threshold (Ct) is defined as the number of heating and cooling cycles required during the PCR process. Ct-values are inversely proportional to the amount of target nucleic acid in a sample.

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The most commonly used molecular diagnostic technique is the polymerase chain reaction (PCR). PCR detects a short section of genetic code of interest, a cancer gene, human mRNA or a pathogen's genome. It is used by every specialty in medicine and surgery, with increasing frequency and importance.

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Article Synopsis
  • Recent SARS-CoV-2 variants have raised concerns about increased transmission within communities, prompting an investigation into their impact on hospital settings.
  • A study analyzed viral sequences and epidemiological data from patients in nine UK hospitals to assess the likelihood of healthcare-associated infections being caused by the Alpha variant versus community-acquired infections.
  • The results indicated no significant difference in the transmission of the Alpha variant compared to other lineages, suggesting existing infection control measures in UK hospitals are effective at containing the spread of emergent variants.
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Article Synopsis
  • The study investigated the impact of the SARS-CoV-2 B.1.1.7 variant on hospitalised patients, focusing on transmission rates and disease severity.
  • Analysis included data from 2,341 inpatients, and results indicated no overall increase in mortality or intensive therapy unit (ITU) admissions associated with B.1.1.7 compared to other variants.
  • However, female patients infected with B.1.1.7 demonstrated a higher risk for ITU admission and a modestly increased risk of mortality.
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