Publications by authors named "E Wiemer"

Article Synopsis
  • Osteoclasts are important cells in bone remodeling, and targeting their apoptosis could help reduce bone loss as people age.
  • The research involved MvpLyz2-Cre mice, which showed that the major vault protein (MVP) plays a protective role against osteoclast formation and is less present in older mice.
  • The study found that knocking out MVP led to decreased apoptosis of osteoclasts, identified its interaction with the Fas receptor, and suggested MVP as a potential target for osteoporosis treatments.
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Article Synopsis
  • The study explores the role of Major Vault Protein (MVP) in macrophages during fracture healing, revealing its importance in the inflammatory response.
  • Macrophage-specific knockout of MVP (MacKO) resulted in impaired transition from pro-inflammatory to anti-inflammatory states, negatively affecting fracture repair.
  • Reintroducing MVP in MacKO mice enhanced healing, highlighting MVP as a potential target for new fracture treatment therapies.
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While the evidence is clear that 2020 voters shifted away from Election Day voting in favor of vote-by-mail and early voting, we know very little about how health risk versus party polarization around risk assessment influenced how and when to vote. We rely on individual-level observational data in the form of high-quality official voter administrative records from the State of New Mexico to ask how pandemic-related risk factors, especially voter age along with partisanship influenced voter decision-making. To identify causal factors, we use a difference-in-differences design and hazard model that compare 2020 general election and primary voter behavior to 2018 and 2016.

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An Ocular Sebaceous Carcinoma (OSC) is a rare malignant tumor for which initial clinical and pathological diagnosis is often incorrect. OSCs can mimic Squamous Cell Carcinomas of the Conjunctiva (SCCC). The aim of this study was to find microRNA biomarkers to distinguish OSCs and SCCCs from normal tissue and from each other.

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Background: Macrophages are implicated in atherosclerotic plaque instability by inflammation and degradation of extracellular matrix. However, the regulatory mechanisms driving these macrophage-associated processes are not well understood. Here, we aimed to identify the plaque destabilization-associated cytokines and signaling pathways in macrophages.

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