Publications by authors named "E Weintraub"
Unmeasured confounding is a major concern in many epidemiologic studies that are not randomized. Negative control methods can detect and reduce confounding by leveraging the proxies of the unmeasured confounders, including negative control outcomes (NCO) and exposures (NCE). An NCO is presumably unaffected by the exposure of interest but would be associated with unmeasured confounders; an NCE presumably does not affect the outcome of interest but would be associated with unmeasured confounders.
View Article and Find Full Text PDFBackground: The JYNNEOS vaccine (two doses given 28 days apart) was recommended in the United States for people at high risk of exposure to monkeypox virus during the 2022 mpox outbreak. Our objective was to assess the safety of JYNNEOS using two complementary epidemiologic methods.
Methods: This observational cohort included patients of eight large integrated healthcare organizations who received JYNNEOS.
Article Synopsis
- A study evaluated the participation rates of the Kaiser Permanente Side Effect Monitor (KPSEM), a self-reporting system for vaccine side effects, among patients receiving COVID-19 vaccinations from April 2021 to July 2023.
- Out of over 2 million vaccinated patients, only about 8% participated, with significant variations based on age and race; younger parents had the lowest rates, while older adults participated the most.
- The findings indicate that socio-economic factors influenced participation, as individuals in lower deprivation areas and certain racial groups were less likely to engage with the system.
Article Synopsis
- A study investigates the effects of receiving seasonal influenza vaccinations during two successive pregnancies on adverse birth outcomes, focusing on differences based on interpregnancy intervals and vaccine types (quadrivalent or trivalent).
- Data was collected from a large cohort of individuals with at least two singleton live births between 2004 and 2018, using information from the Vaccine Safety Datalink.
- The study analyzed risks of complications like preeclampsia, placental issues, and preterm birth among vaccinated and unvaccinated populations, finding that the majority of participants received vaccinations in both pregnancies.
Article Synopsis
- Valid measurement of drug use in clinical trials for substance use disorder is crucial for assessing outcomes, and while self-reports are common, their accuracy varies.
- This study compared self-reports and urinalysis in a methadone treatment program and found that urinalysis often detected more drug use than participants reported, except for heroin.
- The results suggest that relying solely on self-reports could mislead findings on drug use trends, recommending the inclusion of biological tests for more accurate assessments of drug exposure in clinical trials.