Publications by authors named "E Weinstock"
Article Synopsis
- Precontrast CT is typically used to assess hepatic steatosis, but this study investigates the effectiveness of portal venous phase postcontrast CT via AI measurements for detecting moderate steatosis.
- The research analyzed data from 2,777 patients, determining that 13.9% had at least moderate steatosis, revealing significant differences in liver and spleen attenuation measurements between those with and without the condition.
- Results indicated that postcontrast liver attenuation had superior diagnostic performance for detecting moderate steatosis (AUC = 0.938) compared to the postcontrast liver-spleen attenuation difference (AUC = 0.832).
Article Synopsis
- Primary sclerosing cholangitis (PSC) involves harmful inflammation and scarring of bile ducts and has been linked to certain gut bacteria, particularly Klebsiella pneumoniae and Enterococcus gallinarum, found abundantly in PSC patients' fecal samples.* -
- Research shows that carriers of these bacteria experience more severe disease and inflammation, validated through experiments in mice where PSC-related Kp worsens liver injury.* -
- A developed lytic phage cocktail effectively targets and reduces Kp levels, improving liver health in affected mice, suggesting this treatment could be a promising strategy for managing PSC.*
Human gut commensals are increasingly suggested to impact non-communicable diseases, such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a daunting unmet challenge. In four geographically distinct IBD cohorts (n = 537), we identify a clade of Klebsiella pneumoniae (Kp) strains, featuring a unique antibiotics resistance and mobilome signature, to be strongly associated with disease exacerbation and severity. Transfer of clinical IBD-associated Kp strains into colitis-prone, germ-free, and colonized mice enhances intestinal inflammation.
View Article and Find Full Text PDFBackground: Topical antibiotics are frequently used to treat acne vulgaris. Their prolonged use, often for longer durations than recommended, has led to antibiotic resistance in , a bacterium implicated in acne pathophysiology. Bacteriophage (phage), which specifically target by a different mechanism of action and do not harm potentially beneficial bacteria, may offer an alternative approach for improvement of the appearance of acne prone skin.
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