Predictive Factors for Rebleeding after Negative Capsule Endoscopy among Patients with Overt Obscure Gastrointestinal Bleeding.

Background: Although capsule endoscopy (CE) is useful to evaluate obscure gastrointestinal bleeding (OGIB), CE does not always identify the responsible lesions in patients with overt OGIB.

Objectives: To identify factors predictive of rebleeding after negative CE in patients with overt OGIB.

Methods: We retrospectively analyzed the clinical data of 221 patients who underwent CE for overt OGIB.

Capsule endoscopy findings for the diagnosis of Crohn's disease: a nationwide case-control study.

Background: Capsule endoscopy can be used to identify the early stage of small bowel Crohn's disease (CD). We evaluated significant small bowel capsule endoscopy (SBCE) findings that can lead to early diagnosis of CD.

Methods: We retrospectively accumulated clinical and SBCE data of 108 patients (63 with and 45 without CD).

The influence of CYP2C19 polymorphisms on exacerbating effect of rabeprazole in celecoxib-induced small bowel injury.

Background: Simultaneous use of proton pump inhibitors (PPIs) has been shown to increase the risk of nonsteroidal anti-inflammatory drug (NSAID)-induced small bowel injury.

Aim: To investigate whether polymorphisms of the cytochrome P450 2C19 gene (CYP2C19), encoding a key metabolising enzyme for PPIs, are associated with small bowel injury induced by celecoxib in combination with the PPI rabeprazole.

Methods: Study participants included 55 healthy Japanese volunteers, who participated in the PPI-NSAID Kyushu University Study using video capsule endoscopy.

Characteristics of Primary and Metachronous Gastric Cancers Discovered after Eradication: A Multicenter Propensity Score-Matched Study.

Background/aims: Gastric cancers develop even after successful eradication. We aimed to clarify the characteristics of early gastric cancers discovered after eradication.

Methods: A total of 1,053 patients with early gastric cancer treated by endoscopic submucosal dissection were included.

[A case of Turner syndrome (46XXp-/45X) complicated with Crohn's disease after hormone therapy].

A 19-year-old woman, who had been receiving hormone replacement therapy for 13 months before the diagnosis of mosaic Turner syndrome (46XXp-/45X), developed Crohn's colitis and erythema nodosum of the lower legs. Colonoscopy revealed an anal fistula and the presence of deep longitudinal ulcers with cobblestoning in the colorectum. Therapy with prednisolone and adalimumab was effective for the intestinal and skin lesions.