Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis.

Temporoparietal brain areas comprise a candidate set of regions for interrogating the brain functional correlates of socioenvironmental factors in people at clinical high-risk for psychosis (CHR-P). Temporal lobe abnormalities have been shown to be common among people with schizophrenia spectrum conditions. Further, temporoparietal brain regions are implicated in tasks relevant to psychosocial outcomes, including coherent autobiographical memory recall and multimodal integration.

Navigating treatment ambiguities in head and neck squamous cell carcinoma: A retrospective analysis of equivocal PET-CT findings and decision-making strategies following primary non-surgical treatment.

Post-treatment positron emission tomography/computed tomography (PET-CT) scans for head and neck cancer are challenging due to radiation-induced inflammation, leading to equivocal results. The decision by the Leeds-Mid Yorkshire multidisciplinary team (MDT) to proceed with a targeted biopsy or a second PET-CT reflects the uncertainty of balancing timely intervention and potential delays in patient outcomes. A review of the Leeds-Mid Yorkshire radiology database identified 34 head and neck cancer patients with equivocal PET-CT results following chemoradiation between 2019 and 2023.

Antagonism of the antinociceptive effects of fentanyl and the veterinary anesthetic xylazine in mice.

A recent twist to the ongoing tragedy of the opioid epidemic is the adulteration of fentanyl with the veterinary tranquilizer xylazine, an α-adrenoreceptor agonist. Unfortunately, our knowledge of how fentanyl and xylazine interact pharmacologically in different behavioral assays is limited. We examined fentanyl and xylazine alone, with 4 antagonists, and in multiple dose ratio combinations using a 52.

Effects of a single osteopathic manipulative treatment on intraocular pressure reduction: a pilot study.

Context: Research on the effects of osteopathic manipulative treatment (OMT) on visual functions and conditions is very limited. This study continues the exploration on the application of OMT with the intent of lowering intraocular pressure (IOP).

Objectives: A pilot randomized clinical trial was conducted to assess the impact of one OMT session on patients diagnosed with suspected ocular hypertension (OHT) or glaucoma.