Publications by authors named "E W Weidmann"
(1) Background: Posttranslational protein modifications have been demonstrated to change protein allergenicity. Previously, it was reported that pretreatment with highly nitrated food proteins induced a tolerogenic immune response in an experimental mouse model and in human immune cells. Here, we investigated a possible therapeutic effect of modified proteins and evaluated the safety of oral exposure to highly nitrated proteins in an experimental food allergy model.
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- Impaired stomach acid can increase the risk of developing food allergies, so researchers explored how adding a gastric enzyme solution (GES) might help.
- Mice treated with acid suppression medication were tested with GES to see if it could improve their digestion and reduce allergies after being exposed to egg white protein (ovalbumin).
- Results showed that GES helped restore stomach acidity and significantly decreased allergic reactions and antibody levels in the mice, suggesting it could effectively prevent food allergies and lessen allergic symptoms.
Article Synopsis
- - The study investigates how nitrated food proteins affect immune responses related to food allergies, focusing on a mouse model and human immune cells.
- - Mice pretreated with maximally nitrated ovalbumin (nOVAmax) showed reduced allergy-related antibodies and increased regulatory T-cell populations, indicating a potential for developing tolerance.
- - The results suggest that consuming highly nitrated proteins could promote a protective immune response against food allergies by modifying immune cell behavior, particularly through changes in dendritic cells and regulatory T-cells.
Our diet is known to substantially influence the immune response not only by support of mucosal barriers but also via direct impact on immune cells. Thus, it was of great interest to compare the immunological effect of two mouse chows with substantial differences regarding micro-, macronutrient, lipid and vitamin content on the food allergic response in our previously established mouse model. As the two mouse chows of interest, we used a soy containing feed with lower fatty acid (FA) amount (soy-containing feed) and compared it to a soy free mouse chow (soy-free feed) in an established protocol of oral immunizations with Ovalbumin (OVA) under gastric acid suppression.
View Article and Find Full Text PDFRadiographic Measurement of Hindlimb Digit Length in Standing Heifers.
Anat Histol Embryol
December 2016
The digital skeleton of the hindlimbs was evaluated radiographically in 27 standing Brown Swiss heifers. The lateral digital skeleton was significantly longer than its medial counterpart on both a hard (wooden block) and a softer (wooden block covered with a thin rubber mat) surface. There were no significant differences between lengths measured on the hard and the soft surface.
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