Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record.

Many factors, including environmental and genetic variables, contribute to Colorectal Cancer (CRC) risk. Some of these risk factors may share underlying genetics with CRC. We investigated potential shared genetics by performing a Phenome-wide association study (PheWAS) with a multi-ancestry CRC polygenic risk score (PRS).

Delivery Timing of Placenta Accreta Spectrum: Later is Feasible.

Background: Delivery at 34 0/7 - 35 6/7 weeks is recommended for patients with prenatally suspected placenta accreta spectrum (PAS); however, there is limited data to support these recommendations. As a large volume tertiary care center, in an otherwise uncomplicated pregnancy with prenatal concern for PAS, we have historically planned delivery at 36 0/7 - 37 6/7 weeks.

Objectives: To describe the impact of our later delivery timing in cases of suspected PAS on maternal and fetal outcomes.

Fluoroscopy-free Transcatheter Atrial Septal Defect Closure: A Simplified Approach.

Purpose Of Review: To provide an overview of fluoroscopy-free transcatheter atrial septal defect (ASD) closure and introduce a simplified approach that avoids pulmonary vein instrumentation.

Recent Findings: Since the first reported fluoroscopy-free ASD closure 24 years ago, only a few small series have described this technique. We present a simplified and less cumbersome approach to encourage wider adoption of the fluoroscopy-free method to suitable ASD anatomy.