A deep-learning retinal aging biomarker for cognitive decline and incident dementia.

Introduction: The utility of retinal photography-derived aging biomarkers for predicting cognitive decline remains under-explored.

Methods: A memory-clinic cohort in Singapore was followed-up for 5 years. RetiPhenoAge, a retinal aging biomarker, was derived from retinal photographs using deep-learning.

Clinical Impact of Next-Generation Sequencing of T-Cell Lymphomas: A Single Institution Experience.

Background: The understanding of T-cell lymphoma (TCL) pathobiology has grown substantially due to gene expression profiling and high-throughput next-generation sequencing (NGS). However, real-world data on mutational profiles of mature T-cell lymphomas (TCLs) are limited, and their impact on clinical decision making has not been reported.

Methods: A single-institution study of biopsies from patients with histopathologically confirmed T-cell lymphomas and available NGS data between January 1, 2021, to July 1, 2023, was performed.

Spectral normative modeling of brain structure.

Normative modeling in neuroscience aims to characterize interindividual variation in brain phenotypes and thus establish reference ranges, or brain charts, against which individual brains can be compared. Normative models are typically limited to coarse spatial scales due to computational constraints, limiting their spatial specificity. They additionally depend on fixed regions from fixed parcellation atlases, restricting their adaptability to alternative parcellation schemes.

Exploring the anti-obesity effects of Lactobacillus in C57BL/6 mice: mechanisms, interventions, and future directions.

Lactobacillus species show strong potential in fighting obesity-related inflammation and metabolic issues. Obesity causes inflammation in adipose tissue, which harms insulin sensitivity and leads to fat buildup. Lactobacillus strains like Lactobacillus gasseri, Lactobacillus reuteri, and Lactobacillus plantarum help regulate lipid metabolism by boosting key genes, preventing fat cell formation, and encouraging fat breakdown.