Epithelial-to-mesenchymal transition and live cell extrusion contribute to measles virus release from human airway epithelia.

Measles virus (MeV) is a highly contagious respiratory virus transmitted via aerosols. To understand how MeV exits the airways of an infected host, we use unpassaged primary cultures of human airway epithelial cells (HAE). MeV typically remains cell-associated in HAE and forms foci of infection, termed infectious centers, by directly spreading cell-to-cell.

Lossless and reference-free compression of FASTQ/A files using GeneSqueeze.

As sequencing becomes more accessible, there is an acute need for novel compression methods to efficiently store sequencing files. Omics analytics can leverage sequencing technologies to enhance biomedical research and individualize patient care, but sequencing files demand immense storage capabilities, particularly when sequencing is utilized for longitudinal studies. Addressing the storage challenges posed by these technologies is crucial for omics analytics to achieve their full potential.

Highly Pathogenic Avian Influenza A(H5N1) Virus Infections in Humans.

Background: Highly pathogenic avian influenza A(H5N1) viruses have caused widespread infections in dairy cows and poultry in the United States, with sporadic human cases. We describe characteristics of human A(H5N1) cases identified from March through October 2024 in the United States.

Methods: We analyzed data from persons with laboratory-confirmed A(H5N1) virus infection using a standardized case-report form linked to laboratory results from the Centers for Disease Control and Prevention influenza A/H5 subtyping kit.

Determinants of physical activity adoption and maintenance in older adults: A dual process approach.

Background: Dual process models represent a useful framework for explaining physical activity (PA) in that behavior is explained by reflective (i.e., conscious, effortful) and automatic (i.

Patient-specific adaptive planning margin for whole bladder radiation therapy.

Background: Whole bladder irradiation is an organ preservation treatment approach for muscle-invasive bladder cancer (MIBC). Conventional planning margins, typically 15-20 mm, increase normal tissue toxicity and limit possible dose escalation.

Purpose: The study aimed to develop a patient-specific adaptive margin recipe for whole bladder irradiation to minimize the planning target volume (PTV) while preserving adequate dose coverage.