Publications by authors named "E W McKeever"

Importance: During the 2023-2024 respiratory syncytial virus (RSV) season in the United States, 2 new RSV prevention products were recommended to protect infants in their first RSV season: nirsevimab and Pfizer's maternal RSV vaccine. Postlicensure studies are needed to assess prevention product impact and effectiveness.

Objective: To compare the epidemiology and disease burden of medically attended RSV-associated acute respiratory illness (ARI) among children younger than 5 years during the 2023-2024 RSV season with 3 prepandemic RSV seasons (2017-2020), estimate nirsevimab effectiveness against medically attended RSV-associated ARI, and compare nirsevimab binding site mutations among circulating RSV in infants with and without nirsevimab receipt.

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In forest ecosystems, the interplay among plant-driven processes and anthropogenic activities profoundly influences water balance dynamics. Hydraulic redistribution is one plant-driven process that can provide a large proportion of a plant's daily water. However, critical gaps exist in our knowledge of hydraulic redistribution including how forest management processes, like thinning, and site-specific factors like basal area and hillslope position, may affect it.

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Article Synopsis
  • Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants in the U.S., prompting the CDC to recommend nirsevimab, a monoclonal antibody, for infants under 8 months and at-risk children aged 8-19 months to prevent severe infection during their first RSV season.
  • In clinical trials, nirsevimab showed an 81% efficacy rate for preventing RSV-related hospitalizations, while a recent analysis during RSV season (October 2023-February 2024) reported a 90% effectiveness among treated infants.
  • Despite limited numbers of treated infants, the findings support ongoing recommendations for nirsevimab and emphasize the importance of maternal vaccination or direct nirsevimab administration
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  • Adenovirus has been linked to hepatitis in immunocompromised children, but not typically in healthy ones; this changed in April 2022 when unexplained hepatitis cases surfaced in the USA and UK, prompting national surveillance by the CDC.
  • The study focused on children under 10 with unexplained hepatitis and elevated liver enzymes, collecting detailed medical data, caregiver interviews, and specimen testing to identify causes.
  • A total of 377 cases were documented from October 2021 to September 2022, with a median patient age of 2.8 years and a fairly equal distribution of males and females.
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