Publications by authors named "E W Kauffman"
Purpose: To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery.
Background: Left-sided pancreatic cancer is associated with worse OS compared to right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with RPC, current randomized trials included mostly patients with right-sided RPC.
Background: Millions experience inadequately managed acute pain each year. Opioids are an important tool for managing pain; however, recent reductions in opioid prescriptions have exacerbated preexisting challenges in pain management. Moreover, patient expectations and desires for pain management may drive additional opioid use.
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- Xp11 translocation renal cell carcinoma (tRCC) is a rare cancer that mostly affects females and is caused by a fusion of the TFE3 gene on chromosome X with other genes.
- The study explores how TFE3 fusions occur through rearrangements and whether these fusions arise from the active or inactive X chromosomes, shedding light on tRCC's female predominance.
- Findings show that TFE3 fusions are typically due to reciprocal translocations and that specific translocations involving the inactive X chromosome contribute to the higher incidence of tRCC in females, revealing important insights into cancer genetics and sex differences.
Background: Objective and standardized evaluation of surgical skills in robot-assisted surgery (RAS) holds critical importance for both surgical education and patient safety. This study introduces machine learning (ML) techniques using features derived from electroencephalogram (EEG) and eye-tracking data to identify surgical subtasks and classify skill levels.
Method: The efficacy of this approach was assessed using a comprehensive dataset encompassing nine distinct classes, each representing a unique combination of three surgical subtasks executed by surgeons while performing operations on pigs.
Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths.
N Engl J Med
September 2024
Article Synopsis
- The study examines a community-based intervention aimed at reducing opioid-related overdose deaths by increasing the adoption of evidence-based practices including overdose education and naloxone distribution, medication treatment for opioid use disorder, and prescription safety.
- In a cluster-randomized trial, 67 communities across Kentucky, Massachusetts, New York, and Ohio were assigned to either receive the intervention or serve as a control group during a period marked by the COVID-19 pandemic and an increase in fentanyl overdoses.
- Results showed no significant difference in opioid-related overdose death rates between the intervention and control groups, with both averaging similar rates, indicating that the community-engaged strategies did not have a measurable impact during the study period.