Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma.

Background: Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma, a precursor disease of active multiple myeloma for which no treatments have been approved.

Methods: In this phase 3 trial, we randomly assigned patients with high-risk smoldering multiple myeloma to receive either subcutaneous daratumumab monotherapy or active monitoring.

Gender integration of agricultural innovation: implications for the genetically modified crop product development pipeline.

We provide guidance on how to incorporate best practices around gender integration in the development of genetically improved crops by adapting a gender integration framework for conventional crop breeding to the GM product development pipeline, which places greater emphasis on the discovery and launch phases because the technical nature of the development process means fewer opportunities for farmer engagement or pivoting possibilities between these two ends of the product development spectrum. For crop innovation to be relevant to both women and men producers, during the discovery phase, developers can conduct baseline gender analysis consisting of gender-disaggregated value chain analysis, systematic learning about gender-specific crop trait preferences, and identification of varietal preferences by women and men along the value chain. The latter opportunity in the GM product development pathway for intentional gender integration is deployment, including pre-launch activities such as field demonstrations and consumer testing.

pH-Driven Enzymatic Breakdown and Release of Catalase from Alginate Hydrogel.

Stimuli-induced release resulting in biochemical transformations has received a lot of attention due to its application in controlled drug release. In this work, catalase (EC 1.11.

Comparative effectiveness of pre-epiglottic baton plates and mandibular distraction in infants with Robin sequence.

Background: Mandibular distraction osteogenesis (MDO) and pre-epiglottic baton plates (PEBP) are both effective for early management of upper airway obstruction (UAO) in infants with Robin sequence (RS), but have not been directly compared. The purpose of this study was to compare early airway, feeding and growth outcomes between these treatments.

Methods: This is a bicentric retrospective cohort study from 2015-2021 including infants with RS treated with MDO or PEBP before 6 months-of-age with pre- and post-treatment sleep studies and follow-up at least through age 1-year.

Specific, Measurable, Action-Oriented, Realistic, and Timed Goals and the Personal Health Inventory in a Wellness Group for Veterans With GWI.

Background: Interventions based on the Veterans Health Administration's (VHA) Whole Health (WH) initiative may be beneficial for veterans with Gulf War Illness (GWI) through specific, measurable, action-oriented, realistic, and timed (SMART) goal setting and monitoring of perceived goal attainment with the Personal Health Inventory (PHI).

Objectives: This secondary analysis of 2 randomized controlled trials focused on (1) categorizing SMART goals set during a wellness intervention based on the VHA's WH approach to identify goals most relevant for veterans with GWI and chronic pain and (2) descriptively examining the PHI over a course of treatment to assess its preliminary sensitivity to change. Also, changes in PHI for those who engaged in the intervention in-person versus remotely were compared.