A systematic review and meta-analysis of the effectiveness of remdesivir to treat SARS-CoV-2 infection in hospitalized patients: have the guidelines evolved with the evidence?

Background: With progressive accumulation of knowledge on SARS-CoV-2 infection clinical management, treatment guidelines recommended several options including remdesivir (RDV), a broad-spectrum antiviral. Given the evolving nature of COVID-19, capturing the totality of scientific evidence from clinical trials and observational studies is critical to inform clinical decision making. We conducted a systematic literature review (SLR) with meta-analysis (MA) to summarize RDV effectiveness among hospitalized adults.

Viewing Stomata in Action: Autonomous in Planta Imaging of Individual Stomatal Movement.

Stomata regulate plant gas exchange under changing environments, but observations of single stomata dynamics in planta are sparse. We developed a compact microscope system that can measure the kinetics of tens of stomata in planta simultaneously, with sub-minute time resolution. Darkfield imaging with green light was used to create 3D stacks from which 2D surface projections were constructed to resolve stomatal apertures.

Epidemiological and Geographical Factors Associated with Dengue in Bangladesh: A Multicenter Study of the 2023 Dengue Epidemic.

Bangladesh is a well-known epidemic zone for dengue fever. Several epidemiological and geographical factors influence the transmission and severity of dengue infection. This study aimed to determine the epidemiological and geographical factors that contributed to the severity of the dengue outbreak in Bangladesh in 2023.

A simple new method to determine leaf specific heat capacity.

Background: Quantifying plant transpiration via thermal imaging is desirable for applications in agriculture, plant breeding, and plant science. However, thermal imaging under natural non-steady state conditions is currently limited by the difficulty of quantifying thermal properties of leaves, especially specific heat capacity (C). Existing literature offers only rough estimates of C and lacks simple and accurate methods to determine it.

Human Neural Stem Cell Therapy for Traumatic Brain Injury-A Systematic Review of Pre-Clinical Studies.

Human neural stem cells (hNSCs) possess significant therapeutic potential for the treatment of traumatic brain injury (TBI), a leading cause of global death and disability. Recent pre-clinical studies have shown that hNSCs reduce tissue damage and promote functional recovery through neuroprotective and regenerative signaling and cell replacement. Yet the overall efficacy of hNSCs for TBI indications remains unclear.