ROS Responsive Cerium Oxide Biomimetic Nanoparticles Alleviates Calcium Oxalate Crystals Induced Kidney Injury via Suppressing Oxidative Stress and M1 Macrophage Polarization.

Emerging studies have demonstrated that M1 macrophage polarization and oxidative stress play important roles in calcium oxalate (CaOx) induced kidney injury, which leads to increased crystals deposition. ROS scavenging nanozymes and kidney-targeted nanoparticles for antioxidant drugs delivery have emerged as an arisen methodology for kidney injury therapy. However, cell membrane biomimetic-modified nanozymes as anti-inflammatory drug delivery systems for the treatment of kidney injury is rarely reported.

METTL14-mediated mA modification enhances USP22-ERα axis to drive breast cancer malignancy.

The abundance and activity of estrogen receptor alpha (ERα) are tightly regulated by ubiquitin-specific peptidase 22 (USP22) during the progression of breast cancer (BCa). However, the post-transcriptional modifications on the USP22-ERα axis remain elusive. N6-methyladenosine (mA) is critical to modulate RNA status in eukaryotic cells.

The role of teamwork and mentorship in pediatric and congenital heart surgery.

Pediatric and congenital cardiac surgery, characterized by its complexity and high-stakes nature, demands superior technical expertise and multidisciplinary teamwork. With limited surgeons worldwide, the role of continuous skill refinement and collaborative practice is crucial for patient safety and successful outcomes. A literature search was performed using the PubMed, Cochrane, SCOPUS and Web of Science databases for studies published until September 2024.

The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer.

Sine oculis homeobox homolog 1 (SIX1) is a new identified cancer driver in the development of prostate cancer (PC). However, the upstream regulatory mechanisms for SIX1 reactivation in cancer remains elusive. Here, we found that Ku70 robustly interacts with SIX1 in the nucleus of PC cells.

An aza-Diels-Alder approach to nitrogen-containing tetrabenzoacene derivatives.

Acenes and -heteroacenes have been synthesized and studied for over a century because of their fundamentally interesting materials properties and promise for device applications. Within this context, our laboratory has previously synthesized nitrogen-containing tetrabenzo[,,,]pentacenes an aza-Diels-Alder reaction-based approach, and herein, we expand our methodology to obtain substituted, expanded, functionalized, and dimeric tetrabenzoacenes. Overall, our study adds to the limited number of tetrabenzoacene derivatives reported to date and may open further opportunities for these materials in organic optoelectronics applications.