Publications by authors named "E W Dahl"
Background: Proenkephalin A 119-159 (penKid) is a novel blood biomarker for real-time assessment of kidney function and was found to be independently associated with worsening kidney function and mortality. A novel penKid-based estimated glomerular filtration rate equation (eGFR), outperforms current creatinine-based eGFR equations in predicting iohexol or iothalamate plasma clearance-based measured GFR. In this study, we aimed to evaluate the predictive value of penKid and eGFR for all-cause mortality in stable patients at high cardiovascular risk.
View Article and Find Full Text PDFBackground: Due to malnutrition and tumor cachexia, body composition (BC) is frequently altered and known to adversely affect short- and long-term results in patients with cholangiocarcinoma (CCA). Here, we explored immune cell populations in the tumor and liver of CCA patients with respect to BC.
Methods: A cohort of 96 patients who underwent surgery for CCA was investigated by multiplexed immunofluorescence (MIF) techniques with computer-based analysis on whole-tissue slide scans to quantify and characterize immune cells in normal liver and tumor regions.
Protein homeostasis relies on the accurate translation and folding of newly synthesized proteins. Eukaryotic elongation factor 2 (eEF2) promotes GTP-dependent translocation of the ribosome during translation. eEF2 folding was recently shown to be dependent on Hsp90 as well as the cochaperones Hgh1, Cns1, and Cpr7.
View Article and Find Full Text PDFArticle Synopsis
- Neonatal abstinence syndrome (NAS) is a condition affecting infants due to in-utero exposure to substances, particularly opioids, and can cause long-term developmental issues; interdisciplinary teams can help mitigate these effects but often lack adequate training and support.* -
- Project SCOPE aimed to enhance the capabilities of providers working with NAS-affected families by training 14 sites in the ECHO model and SCOPE curriculum, which they implemented over 2019-2022, reaching about 9,392 individuals in 33 states.* -
- Analysis of participant surveys revealed high satisfaction (96.4%) with the sessions, significant gains in knowledge and skills related to NAS, and increased motivation to work with affected populations; nearly
Article Synopsis
- - Cholangiocarcinoma (CCA) is a type of aggressive bile duct cancer with limited prognostic markers and targets; however, the gene ITIH5, known for its tumor-suppressing functions, has been found to be upregulated in CCA, making it a promising marker for detection and prognosis.
- - A study involving 175 CCA patients showed that high ITIH5 protein expression was linked to better survival rates, lower cancer stages, and reduced perineural invasion, indicating its potential as a useful biomarker.
- - The findings suggest that ITIH5 could serve both as a marker for early detection through blood tests and a prognostic indicator in tissue samples, especially in cases of intrahepatic C