Publications by authors named "E W Carlson"
Introduction: We investigated whether the cerebellum develops neuropathology that correlates with well-accepted Alzheimer's disease (AD) neuropathological markers and cognitive status.
Methods: We studied cerebellar cytoarchitecture in a cohort (N = 30) of brain donors. In a larger cohort (N = 605), we queried whether the weight of the contents of the posterior fossa (PF), which contains primarily cerebellum, correlated with dementia status.
Article Synopsis
- - Penicillin-binding proteins (PBPs) are crucial bacterial enzymes that can be inhibited by β-lactam antibiotics, disrupting their ability to grow and divide, ultimately leading to cell lysis.
- - Traditional metrics like IC values for measuring enzyme inhibition can be misleading, especially for covalent inhibitors, making the second-order rate constant (k) a better measure of potency.
- - The researchers created a whole-cell k assay using a fluorescent probe to assess β-lactam potency across multiple PBPs, confirming its effectiveness in relation to existing IC values and supporting further structure-activity relationship studies.
Excessive alcohol use damages the brain, especially corticolimbic regions such as the hippocampus and rhinal cortices, leading to learning and memory problems. While neuroimmune reactivity is hypothesized to underly alcohol-induced damage, direct evidence of the causative role of microglia, brain-resident immune cells, in this process is lacking. Here, we depleted microglia using PLX5622 (PLX), a CSF1R inhibitor commonly used in mice, but rarely in rats, and assessed cell death following binge-like alcohol exposure in male rats.
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- * In a four-week challenge, 46 medical students engaged in health screenings and nutrition seminars, resulting in significant weight loss and reductions in blood pressure.
- * Results showed a strong push from participants for more nutrition education in medical schools, indicating that integrating such topics could enhance long-term patient health outcomes.
Effects from aging in single cells are heterogenous, whereas at the organ- and tissue-levels aging phenotypes tend to appear as stereotypical changes. The mammary epithelium is a bilayer of two major phenotypically and functionally distinct cell lineages: luminal epithelial and myoepithelial cells. Mammary luminal epithelia exhibit substantial stereotypical changes with age that merit attention because these cells are the putative cells-of-origin for breast cancers.
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