The nature of the background in radionuclide ventriculography: deductions from the mathematical behaviour of the ejection fraction.

The relationship between the ejection fractions calculated from 'uncorrected' radionuclide time activity curves (UEF) and angiographic ejection fractions (AEF) in 200 catheterized patients yielded the regression equation AEF = 1.74 UEF + 0.21.

Asymmetric distribution of left ventricular asynergy in coronary artery disease and its relation to coronary stenoses.

In 100 patients with coronary artery disease (CAD), the prevalence and severity of asynergy was determined for 9 left ventricular (LV) segments by both radionuclide and contrast angiography. The anterior, septal and lateral LV walls had significantly more prevalent and more severe asynergy in the medial segments than in the basal segments. In contrast, the inferior LV wall exhibited equally severe asynergy in both the medial and basal segments.

No increase in serum digoxin concentration with high-dose diltiazem.

The effect of incremental diltiazem dosing during concomitant digoxin administration over a four-week period in eight healthy adult volunteers (mean age, 28 +/- 4 years) was studied. The study group received 0.25 mg of digoxin twice daily for two days, after which they received 0.