Publications by authors named "E Vink-Borger"
Aim: The term 'intramucosal carcinoma' in the colorectum is controversial when used as a synonym for high-grade dysplasia. However, setting clear definitions for this diagnosis (i.e.
View Article and Find Full Text PDFAims: Traditionally, mismatch repair (MMR) status is determined by a panel of four antibodies (MLH1, PMS2, MSH2, MSH6). If all proteins are retained, cases are MMR proficient (pMMR), while loss of one or more proteins is indicative of MMR deficiency (dMMR). This approach has been challenged in favour of a two-antibody approach, using PMS2 and MSH6 as a first screening.
View Article and Find Full Text PDFAim: Currently, screening of colorectal cancers (CRC) by assessing mismatch repair deficiency (dMMR) or microsatellite instability (MSI) is used to identify Lynch syndrome (LS) patients. Advanced adenomas are considered immediate precursor lesions of CRC. In this study we investigate the relevance of screening of advanced adenomas for LS in population screening.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the prognostic value of the Immunoscore in Stage I/II colon cancer patients, using data from over 1,800 individuals across North America and Europe.
- Results indicated that a high Immunoscore correlated with lower recurrence rates and better survival outcomes, especially significant in Stage II and high-risk Stage II patients.
- The findings suggest that a low Immunoscore can effectively identify early colon cancer patients at risk of relapse, even when accounting for other clinical factors.