Publications by authors named "E Vincent Faustino"
Demographic diversity in platelet function and response to antiplatelet therapy.
Trends Pharmacol Sci
January 2025
Recent studies have highlighted the complexity of platelet biology, revealing their diverse roles beyond hemostasis. Pathological platelet activation is now recognized as a key contributor to thrombosis and inflammation that are both central to cardiovascular disease (CVD). Emerging research emphasizes the significant impact of demographic factors - such as age, sex, race, and ethnicity - on CVD risk and responses to antiplatelet therapies.
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- The study investigates the effectiveness of enoxaparin, a medication for preventing blood clots, in critically ill children, focusing on differences in response based on age, particularly between older children and infants.
- It consists of two simultaneous clinical trials: one for older children aged 1-17 years, and another for infants under 1 year, with specific dosing protocols for each group.
- The trials are set in multiple pediatric intensive care units across the U.S., using methods like randomization, ultrasonography, and blood analysis to assess outcomes and monitor safety.
Article Synopsis
- The study aimed to understand what factors disrupt children's sleep in Pediatric Intensive Care Units (PICUs) as reported by their parents.
- A survey was conducted among parents in four PICUs and a pediatric sleep laboratory, with results indicating that 71% of children experienced significant sleep disruptions, primarily due to pain (38%) and lack of a home-like schedule (26%).
- Findings suggest that critical care environments uniquely affect children's sleep, highlighting the need for tailored sleep promotion strategies in PICUs.
Article Synopsis
- Research highlights a critical gap in understanding long COVID (PASC) in children and emphasizes the need for studies that define its characteristics in this age group.
- The objective is to identify common prolonged symptoms in children aged 6 to 17 post-SARS-CoV-2 infection, examining differences between school-age kids and adolescents, as well as potential symptom clusters for future research.
- A multicenter study involved nearly 5,000 participants, revealing that certain symptoms were significantly more prevalent in those with a history of COVID-19 compared to those without.
Article Synopsis
- Congenital heart disease (CHD) is linked to both clotting and bleeding risks, with past studies showing mixed results on platelet activity in affected infants, prompting this investigation.
- The study enrolled 19 infants with CHD and 21 controls, using advanced mass spectrometry to analyze platelet surface markers and cytokine levels in the blood.
- Results indicated significant differences in platelet activation in CHD infants, revealing unique subpopulations of platelets, increased hypogranular platelets, and elevated plasma cytokines, suggesting complex platelet behavior in this condition.