Publications by authors named "E Vijaya Bharathi"

Contaminants are repeatedly being released into the land, water and air about the world as a consequence of the high levels of human movement and development, which causes a fast an increase in the growing of pollution. In this assessment, activated charcoals supported on Ag-InO nanomaterials were blended by hydrothermal system. The morphology constitution, surface assets and optical description of synthesized nanomaterials were characterized by XRD, UV-DRS, PL, HR-SEM and EDAX, HR-TEM, SAED pattern, FT-IR, XPS, BET, CV and VSM techniques.

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In 2017, Tamil Nadu, a southern state, had the second highest number of dengue cases from India. In the present study, the serotype-specific differences in the clinical manifestations and laboratory parameters among hospitalized children with dengue were investigated and molecular characterization of the circulating dengue virus (DENV) serotypes during 2017 in Tamil Nadu was performed. Eighty children with dengue-like symptoms consecutively admitted to a tertiary care hospital and positive for DENV NS1 antigen were investigated for DENV serotype utilizing a real-time reverse transcriptase based polymerase chain reaction assay.

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Several families of protein kinases have been shown to play a critical role in the regulation of cell cycle progression, particularly progression through mitosis. These kinase families include the Aurora kinases, the Mps1 gene product and the Polo Like family of protein kinases (PLKs). The PLK family consists of five members and of these, the role of PLK1 in human cancer is well documented.

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Article Synopsis
  • The success of imatinib for chronic myelogenous leukemia has spurred interest in developing new kinase inhibitors with lower toxicity.
  • Researchers analyzed over 150 new cyano pyridopyrimidine compounds to identify trends for creating effective multikinase inhibitors.
  • The lead compound, 7x, showed promising results by inducing tumor cell death at low concentrations and effectively inhibiting key kinases involved in cancer progression.
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Article Synopsis
  • A new series of (E)-N-aryl-2-arylethenesulfonamides were developed and showed strong anticancer effects across various resistant cancer cell lines, with IC50 values between 5 to 10 nM.
  • In vivo tests in nude mice demonstrated that one compound, (E)-N-(3-amino-4-methoxyphenyl)-2-(2',4',6'-trimethoxyphenyl)ethenesulfonamide (6t), significantly reduced tumor sizes and appeared to have better blood-brain barrier permeability compared to existing cancer drugs.
  • Mechanistic studies revealed that compound 6t disrupts microtubule formation and arrests cancer cells during mitosis, while also overcoming drug
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