Publications by authors named "E Vigliar"
Interventional cytopathologist perspective on the Milan System Classification: a study on 929 consecutive salivary gland fine-needle aspirations with a focus on challenging diagnostic categories.
Pathologica
December 2024
Background: Although the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has improved the diagnosis and management of salivary gland lesions, determining the risk of malignancy (ROM) for AUS and SUMP categories remains challenging. We investigated the role of interventional cytopathologists in refining the differential diagnosis of these categories.
Methods: We searched for salivary gland fine-needle aspirations (FNAs) performed at our Institution since the publication of the first edition of MSRSGC.
Objective: ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations represent fundamental predictive biomarkers for advanced non-small cell lung cancer (NSCLC) patients to ensure the best treatment choice. In this scenario, RNA-based NGS approach has emerged as an extremely useful tool for detecting these alterations. In this study, we report our NGS molecular records on ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations detected by using a narrow RNA-based NGS panel, namely SiRe fusion.
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- Thyroid and salivary gland cytopathology often present diagnostic challenges due to overlapping features and rare conditions, prompting a focused seminar at the 45th European Congress of Cytology to address these issues.
- The seminar showcased complex cases using fine-needle aspiration cytology (FNAC) alongside histopathological and molecular analyses to differentiate between benign and malignant lesions.
- The findings emphasize the necessity of a comprehensive, multidisciplinary diagnostic approach that integrates cytological, clinical, and histopathological data for accurate patient management.
In elderly patients with high-risk classic Hodgkin lymphoma (c-HL), we evaluated the impact of a new modality treatment without bleomycin, that is, liposomal doxorubicin (NPLD)-based regimen plus consolidation radiotherapy of residual nodal masses (RNMs), on overall survival (OS) and progression free survival (PFS). In this retrospective study (2013-2023) conducted in tertiary hospitals in the bay of Naples (Italy), 50 older adults (median age, 69 years; range, 60-89) with advanced stage c-HL received frontline treatment with MVD ± irradiation. MVD consisted of 25 mg/m of NPLD along with standard Vinblastine and Dacarbazine for a total of 6 cycles (twelve iv administrations, every 2 weeks) followed by radiation of RNMs with size ≥ 2.
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- Fine needle cytology (FNC) is an important method for differentiating between benign and malignant lymph node conditions due to its low invasiveness, affordability, and high accuracy.
- Proper management of the samples collected during the procedure is crucial for achieving the best diagnostic results, particularly through careful examination of the cellular structures.
- The text discusses a specific pattern called 'concentric ovals distribution,' often seen in benign lymph nodes, which can help cytopathologists accurately diagnose reactive hyperplasia.