Regional cerebral blood flow in weight-restored anorexia nervosa: a preliminary study.

Twenty-one individuals (19 females, two males) with teenage-onset anorexia nervosa (AN), 19 of whom were weight restored, were assessed using single-photon emission computed tomography (SPECT) 7 years after onset of AN, at a mean age of 22 years. For comparison we recruited a younger group without neuropsychiatric disorder (mean age 9:8 years; five females, four males) who underwent SPECT at follow-up after an operation for coarctation of the aorta or because of lymphatic leukaemia. Ethical considerations precluded the study of regional cerebral blood flow (rCBF) in participants with completely normal development.

Administered activity of 99Tcm-MAG3 for gamma camera renography in children.

A method of calculating the activity of 99Tcm-MAG3 to be administered to children of different ages has been developed and evaluated. The suggested administered activity schedule is only valid for estimation of split renal function. The activity required to obtain the same count rate over the kidneys for all ages was calculated as a fraction of the activity administered to an adult by using a biokinetic model and taking attenuation effects into account.

Administered activity of 99Tcm-DMSA for kidney scintigraphy in children.

Kidney scintigraphy using 99Tcm-dimercaptosuccinic acid (DMSA) is a common gamma camera investigation in paediatric patients. The present study deals with methods of calculating the activity to be administered to children. Our aim is to find a method of calculation which gives the same count density in the gamma camera images for all ages.

Regional cerebral blood flow abnormalities in Rett syndrome.

Sixteen Rett syndrome (RS) girls and 1 24 year old RS woman were compared with 16 neurologically healthy children as to the regional cerebral blood flow (rCBF). Hypoperfusion of the frontal lobes and parts of the midbrain was found in RS, with significant differences to controls at latest by the age of three to four years. The findings were in accordance with previous reports of morphological, neuroradiological and functional abnormalities in these areas, compatible with a statement that structures in the midbrain and in the frontal lobes may have particular pathophysiological relevance in RS.

Radiopharmaceutical dosage of 99Tcm-HMPAO for cerebral blood flow SPET studies in children.

Four methods of calculating the activity of 99Tcm-hexamethylpropyleneamine oxime to be administered in cerebral blood flow investigations of children were evaluated in patient studies. Three of the methods were based on the size of the child. We also constructed a theoretical dosage model based on physiological data and attenuation effects.