Publications by authors named "E Verna"
Hepatocellular carcinoma (HCC) surveillance is recommended by liver professional societies but lacks broad acceptance by several primary care and cancer societies due to limitations in the existing data. We convened a diverse multidisciplinary group of cancer screening experts to evaluate current and future paradigms of HCC prevention and early detection using a rigorous Delphi panel approach. The experts had high agreement on twenty-one statements about primary prevention, HCC surveillance benefits, HCC surveillance harms, and the evaluation of emerging surveillance modalities.
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- The study analyzes the impact of liver transplant allocation policies through acuity circles (ACs) on the dynamics of race and gender concerning waitlist mortality and the receipt of deceased donor liver transplants (DDLT).
- Using data from 59,592 patients over a period before and after AC implementation, the research found no significant changes in how race and gender interacted concerning DDLT access or waitlist mortality.
- Black and Hispanic women showed persistent disparities, with lower rates of receiving DDLT and higher waitlist mortality compared to White women, while men across races fared better in these areas, highlighting ongoing inequalities in transplantation outcomes.
Background: Transjugular intrahepatic portosystemic shunt (TIPSS) is highly effective for treatment of variceal bleeding; however, factors contributing to rebleeding complications remain unclear.
Aims: In this study, we aim to determine risk factors for recurrent portal hypertensive gastrointestinal bleeding following TIPSS.
Methods: Utilising the Advancing Liver Therapeutic Approaches multicentre database, we retrospectively identified adult patients who underwent TIPSS for secondary prophylaxis of variceal bleeding and had a gastrointestinal rebleeding event within 1 year.
Article Synopsis
- Alcohol-associated hepatitis (AH) has high mortality rates, with up to 40% of patients dying within 6 months, partly due to increased susceptibility to infections that worsen their condition.
- A study analyzed the immune responses of 36 healthy individuals, 48 patients with alcohol use disorder, and 224 AH patients, finding that abstaining from alcohol boosts antibody responses, while AH patients had reduced antiviral and antibacterial antibodies linked to worse outcomes.
- The research indicates that a lower level of antiviral antibodies in AH patients can predict liver disease complications and mortality, suggesting that serum viral epitope signatures could be valuable for assessing patient prognosis.
Background And Aims: While transjugular intrahepatic portosystemic shunt (TIPS) is traditionally considered a bridge to liver transplant (LT), some patients achieve long-term transplant-free survival (TFS) with TIPS alone. Prognosis and need for LT should not only be assessed at time of procedure, but also re-evaluated in patients with favorable early outcomes.
Approach And Results: Adult TIPS recipients in the multicenter Advancing Liver Therapeutic Approaches retrospective cohort study were included (N=1,127 patients; 2,040 person-years follow-up).