Publications by authors named "E Venanzi Rullo"
Article Synopsis
- Fibroblastic and myofibroblastic neoplasms are a significant portion (12%) of pediatric soft tissue tumors, mostly benign or locally aggressive with infrequent metastasis.
- Diagnosing these tumors is complicated due to their similar appearances and limited effectiveness of immunohistochemistry, but advancements in RNA sequencing have shed light on their molecular drivers and improved classification.
- Key molecular changes, like RTK and MAPK activation, are important in tumors such as infantile fibrosarcoma and inflammatory myofibroblastic tumors, with ongoing research identifying new RTK-driven lesions that require attention in classification.
Article Synopsis
- Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) is a fixed-dose combination therapy found to be effective for people living with HIV who switched from other treatments.
- A study involving 127 patients showed that virological suppression improved from 66.4% to 74.8% over 96 weeks, along with significant increases in CD4 and CD8 T cell counts and the CD4/CD8 ratio.
- The treatment was associated with lower levels of triglycerides and total cholesterol, indicating a better metabolic profile, although there was a notable increase in serum creatinine levels.
Laryngeal cancer accounts for one-third of all head and neck tumors, with squamous cell carcinoma (SCC) being the most predominant type, followed by neuroendocrine tumors. Chromogranins, are commonly used as biomarkers for neuroendocrine tumors, including laryngeal cancer. It has been reported that secretogranin VGF, a member of the chromogranin family, can be also used as a significant biomarker for neuroendocrine tumors.
View Article and Find Full Text PDFArticle Synopsis
- * Three datasets were compiled for phylogenetic analysis including Italian and international sequences, revealing various clustering patterns of the variants, with a significant proportion of Italian sequences.
- * The findings indicate different evolutionary dynamics among the variants, showing that transmissibility and public health measures influenced the replacement mechanisms of SARS-CoV-2 variants in the population.