Publications by authors named "E Vasilescu"
Article Synopsis
- The study investigates how B cell populations and their receptors evolve in the intestines of humans, particularly after intestinal transplantation, using biopsies for observation.
- Researchers employed advanced techniques like polychromatic flow cytometry and B cell receptor sequencing to differentiate between donor and recipient B cells and assess their development in the transplanted intestines.
- Findings reveal that recipient B cells, including memory B cells, rapidly populate the transplanted intestines mainly in infants, and their B cell receptors evolve differently in the graft compared to circulation, with notable clonal mixing remaining years after the transplant.
Although a few registry-based studies have shown associations between receiving kidney allografts from Black donors and shorter allograft survival, detailed, large, single-center studies accounting for common confounding factors are lacking. Furthermore, pathologic alterations underlying this potential disparity have not been systematically studied. We performed a retrospective clinical-pathological study of kidney transplant recipients who received kidney allografts from either Black ( = 407) or White ( = 1,494) donors at Columbia University Irving Medical Center from 2005 to 2018, with median follow-up of 4.
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- The study examines how B cell populations and their receptors (BCRs) are formed and maintained in the intestine after intestinal transplantation (ITx).
- Researchers used advanced techniques to analyze B cells from both donors and recipients, revealing that recipient B cells, including memory B cells, quickly established themselves in the transplant's mucosa, especially in infants.
- Despite ongoing changes in B cell populations post-transplant, there is no evidence of a stable B cell repertoire being formed in the gut tissue, even years after the procedure.
We report a novel HLA-B*58 allele, now named B*58:141, identified by next-generation sequencing.
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