Nanocrystal formulations of mebendazole employing quality by design and molecular level insights by atomistic simulations.

Objective: The present study investigates the production of mebendazole nanocrystal formulations by wet media milling.

Significance: Nanocrystal formulations are expected to enhance the dissolution properties of mebendazole, which possesses poor solubility, highly dependent on crystal polymorphism.

Methods: A Box-Behnken design was employed to study the effects of formulation and process variables on the nanocrystal size and ζ-potential.