Publications by authors named "E Van Dyck"
Background: Epidemiological studies suggest that metformin reduces the risk of developing several types of cancer, including gliomas, and improves the overall survival in cancer patients. Nevertheless, while the effect of metformin on cancer cells has been extensively studied, its impact on other components of the tumour microenvironment, such as macrophages, is less understood.
Results: Metformin-treated mouse bone marrow cells differentiate into spindle-shaped macrophages exhibiting increased phagocytic activity and tumour cell cytotoxicity coupled with modulated expression of co-stimulatory molecules displaying reduced sensitivity to inflammatory cues compared with untreated cells.
Completing the Circle: A History of Psychedelics and Harm Reduction.
Curr Top Behav Neurosci
August 2024
Harm reduction officially entered the public health lexicon in the 1980s as a response to the HIV/AIDS crisis and its spread amongst intravenous drug users, but risk prevention has been an important part of psychedelic consumption in ways that predate this formal conceptualization.We look at psychedelic drug trials in the 1950s and 1960s to consider how people-first perspectives informed those early clinical studies, and how pioneering psychedelic researchers themselves approached risk management at a time that predates the formal recognition of harm reduction. Next, we follow psychedelic drugs out of the clinic and into music scenes and festivals that proliferated during the war on the drugs, where community-based organizations stepped up to support music fans who chose to combine psychoactive substances with dancing and drugs at all-day festivals.
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- The study aimed to evaluate the effectiveness of early medical prophylaxis versus waiting for endoscopy findings in preventing postoperative recurrence (POR) in patients with Crohn's disease after ileocaecal resection (ICR).
- Out of 346 patients, those receiving early prophylactic treatment (Cohort 1) had significantly lower endoscopic recurrence rates compared to those who only received treatment based on endoscopy results (Cohort 2).
- While both groups did not show significant differences in severe endoscopic POR or time to surgical recurrence, the proactive group had a lower treatment burden when using immunomodulators.
Article Synopsis
- - Illicit drug use is prevalent at music festivals, prompting research into whether attendees intentionally plan to use drugs or if they're influenced by their environment, like peer presence or the perception that everyone is using drugs.
- - The study utilized the prototype willingness model to evaluate if drug use decisions at festivals are made logically or impulsively, surveying attendees before, during, and after the event.
- - Results showed that positive attitudes towards drug use and a self-identity aligned with drug-using attendees significantly influenced intentions to use drugs, indicating that both rational and spontaneous decisions contribute to substance use at festivals.