Publications by authors named "E Van Aken"
Age-related macular degeneration (AMD) is an age-related disorder that is a global public health problem. The non-enzymatic Maillard reaction results in the formation of advanced glycation end products (AGEs). Accumulation of AGEs in drusen plays a key role in AMD.
View Article and Find Full Text PDFThe consensus in aging is that inflammation, cellular senescence, free radicals, and epigenetics are contributing factors. Skin glycation through advanced glycation end products (AGEs) has a crucial role in aging. Additionally, it has been suggested that their presence in scars leads to elasticity loss.
View Article and Find Full Text PDFPresbyopia is an age-related vision disorder that is a global public health problem. Up to 85% of people aged ≥40 years develop presbyopia. In 2015, 1.
View Article and Find Full Text PDFArticle Synopsis
- Over 2 billion people globally have vision impairments, often linked to age and diabetes-related eye diseases, with advanced glycation end products playing a significant role in their development.
- Research has focused on fructosamine-3-kinase (FN3K) as a promising therapeutic, necessitating understanding of its stability and behavior in the eye.
- The study found that FN3K produced in yeast (Pichia pastoris) had higher yield and purity than in E. coli, and initial tests showed FN3K maintains mobility in vitreous fluid, paving the way for future pharmacokinetics studies.
Lose the Nintendo and thou shall be healed! Restoring vision in malingering.
GMS Ophthalmol Cases
February 2022
Non-organic visual loss can be hard to prove or explain to the parents of affected children at times. Here, we describe a simple yet effective approach that may help solve both issues by ensuring that the patient refrains from visual stimuli.
View Article and Find Full Text PDF