[Artificial intelligence in ultrasound diagnosis of thyroid nodules].

Objective: To analyze the efficacy of the S-Detect AI system of the Samsung RS85 ultrasound scanner (South Korea) in stratifying thyroid nodules compared to data obtained by specialist of ultrasound diagnostics.

Material And Methods: In 2024, we analyzed ultrasound data of 80 patients with thyroid nodules who required fine-needle aspiration biopsy (FNAB). Patients underwent thyroid ultrasound with nodule assessment according to the EU TI-RADS classification (GE Voluson E8 scanner, USA).

[Compression elastography as a new method of ultrasound imaging in the differential diagnosis of chronic tonsillitis].

Unlabelled: Chronic tonsillitis remains as an urgent problem in modern otorhinolaryngological practice, which requires improving the diagnostic methods of this pathology.

Objective: To increase the diagnostic information content of objective methods for differential diagnosis of different forms of chronic tonsillitis.

Material And Methods: The study involved 97 patients who were divided into two groups: the 1st group (39 patients) - with a simple form; the 2nd group (58 patients) - with a toxic-allergic form of chronic tonsillitis.

In Vitro Study of Cytostatic Activity of Baicalin, Baicalein, and Chlorophyllipt on HeLa-v Cell Line.

Cytostatic activity of baicalin, baicalein, and neogalenical drug Chlorophyllipt was studied in vitro on HeLa-v cells. Standard samples of Eucalimin, baicalin, and baicalein, as well as Chlorophyllipt and paclitaxel (reference drug Taxacad) were used. The cell deaths were determined by MTT assay in a Multiskan FC microplate reader with incubator.

Predictive significance of HIF-1α, Snail, and PD-L1 expression in breast cancer.

Currently, the prediction of breast cancer (BC) effectiveness to drug treatment is based on determining the expression level of steroid hormone receptors and human epidermal growth factor receptor type 2 (HER2). However, significant differences in individual response to drug treatment require the search for new predictive markers. Here, by comprehensively examining HIF-1α, Snail, and PD-L1 expression in BC tumor tissue, we demonstrate that high levels of these markers correlate with unfavorable factors of BC prognosis: the presence of regional and distant metastases and lymphovascular and perineural invasion.

Physicochemical and Biological Characterization of rhC1INH Expressed in CHO Cells.

The disfunction or deficiency of the C1 esterase inhibitor (C1INH) is associated with hereditary or acquired angioedema (HAE/AAE), a rare life-threatening condition characterized by swelling in the skin, respiratory and gastrointestinal tracts. The current treatment options may carry the risks of either viral infection (plasma-derived Berinert) or immune reaction (human recombinant C1INH from rabbit milk, Ruconest). This study describes the physicochemical and biological characterization of a novel recombinant human C1 esterase inhibitor (rhC1INH) from Chinese hamster ovary (CHO) cells for the treatment of hereditary angioedema compared to the marketed products Berinert and Ruconest.