[The role of cerebral activation in the sleep-wake cycle].

The development of views on cerebral activation in the wakefulness-sleep cycle, starting with the work of Constantin von Economo, is considered. The emphasis is on the cyclic activation of high-amplitude discharges in sleep, which, with known assumptions, can include K-complexes, as well as patterns of delta-like waves. Considering the participation of the peripheral nervous system in this, the integrative role of cyclic activation of high-amplitude discharges in the organization of the sleep-wake cycle is discussed.

[Sleep regulation as a complex process].

A retrospective analysis of views on the regulation of the «sleep-wakefulness» cycle from the reticular theory of sleep to the Saper's model was carried out. A modified version of the Saper's trigger made it possible to use the results of a comparative analysis of drugs used in the treatment of sleep disorders to develop new, comprehensive, effective approaches to the pharmacotherapy of the most common sleep disorders. It seems that this approach will be useful in the development of effective pharmacotherapy for sleep disorders.

[Anxiety and sleep in experiment and clinic].

High anxiety is a genetically determined personal trait. It is produced by limbic system and other cerebral structures involved in maintenance of wakefulness and development of sleep. Analysis of experiments on the animals and clinic observations showed that animals and individuals with high personal anxiety have a high risk of anxiety disorders.