Ethylenediamine-modified alginate - A hemocompatible platform for polymer-drug conjugates.

The study is dedicated to the synthesis, rheological properties, hemocompatibility, and further modification of water-soluble derivatives of sodium alginate containing fragments of ethylenediamine (Alg-EDA). Alg-EDA with an equal ratio of amide/amine groups and varying degrees of substitution were synthesized by the carbodiimide method. The influence of the molecular weight of Alg-EDA on the attachment of bioactive molecules such as hydroxybenzoic and ferulic acids was determined.

Hemorrhagic Activity of Cationic Starch Conjugates with Sterically Hindered Phenol after Intravenous Administration to Guinea Pigs.

Intravenous injection of cationic starch conjugated with sterically hindered phenol (terpenophenol) to guinea pigs did not increase hemorrhagic activity (in doses of 2 and 4 mg/kg) and plasma clotting time in activated partial thromboplastin time and prothrombin time tests (in a dose of 4 mg/kg) in comparison with administration of physiological saline. Intravenous injection of the cationic starch conjugate with the highest content of terpenophenol fragments (4.1%wt) in a dose of 2 mg/kg to guinea pigs leads to a decrease in hemorrhagic activity by 4 times in comparison with the control.

Hemocompatibility, biodegradability and acute toxicity of acetylated cellulose nanocrystals of different types in comparison.

Promotion of promising cellulose nanocrystals (CNC) is largely dependent on the relationship between their morphology, surface chemical composition, and supramolecular structure with toxicity, hemocompatibility, and biodegradability. This paper outlines comparative and integrated analysis of the mentioned biocompatibility aspects of partially acetylated rod-, and disc-lake morphology of CNC with crystalline cellulose allomorphs I and II. These data have also included the study of CNC obtained from the sulfuric acid solutions.

Synthesis and hemocompatibility of amino (di-)butyldeoxy modified hydroxyethyl starch.

Cationic polymers are of interest as the basis for obtaining various biomaterials. Hydrophilic biopolymers and their modification products are of main interest. Biocompatibility is the prime criterion that makes this material usable for said purposes.

Disk-like nanocrystals prepared by solvolysis from regenerated cellulose and colloid properties of their hydrosols.

One possible way of obtaining cellulose nanocrystals and aqueous sols with novel properties is based on modification of supramolecular structure of the polysaccharide. This modification involves rearrangements of hydrogen bonds and has an effect on polymer morphology, formation of surface reactive sites and interface interactions. Disc-like nanocrystals of cellulose II were prepared by solvolysis of regenerated cellulose in acetic acid/octanol medium in the presence of 0.