[Effect of saccharol glycosides on energy metabolism in animals with abnormal carbohydrate tolerance].

A trial has been performed of a new sweetening agent saccharol, glycosides complex, on energy metabolism in rats with experimental alloxan diabetes. Elevated glucose level observed in rats with insulin insufficiency was associated with hexokinase activity inhibition and changes in the activity of the enzymes involved in glucose-6-phosphate transformation: enhanced activity of glucose-6-phosphatase and glucose-6-phosphate dehydrogenase against inhibition of phosphoglucomutase activity. Introduction of saccharose aggravated the above shifts in the rat liver, whereas saccharol possesses a protective action on hexokinase hepatic reaction and enzymes of glucose-6-phosphate conversion, reduced blood glucose.

[Effect of a new sweetening agent from Stevia rebaudiana on animals].

Animals received saccharol adequate (by sweetness) to sugar, and in 10- and 50-fold increased amounts. The data of chronic 10-month experiments studied in the time course after 2, 5, 10 months have permitted a conclusion that saccharol included into the ration during long periods, does not produce a significant effect on the parameters of metabolic processes and morphological picture of the internal organs in test animals. Saccharol in 50-fold increased amounts inhibits the activity of oxidative phosphorylation in the hepatic tissue of rats.

[Effect of a new exopolysaccharide on animal body].

The influence of new exopolysaccharide, synthesized by Candida tropicalis and Pseudomonas sp. consortium in ethanol, on the animal body was studied in chronic experiments conducted in 200 non-inbred white rats. The animals were sacrificed after 3, 10 and 18 months of follow-up.

[Effects of a new saccharose-containing powder on the indicators of carbohydrate and lipid metabolism in animals].

Experimental animals were fed with semisynthetic rations with sugar-containing powder (40% of carbohydrate energy value) during 10 months. It has been found that this ration does not influence the levels of glucose in the blood, glycogen in the liver, and the content of triglycerides, total cholesterol and alpha-lipoprotein cholesterol in the blood serum. Similar quantity of refined sugar in the ration led to elevation of the levels of glucose in the blood, of triglycerides and total cholesterol in the blood serum by the end of the experiment.

[Effect of sugar beet saponins on the body of animals].

A study was made of the effect of sugar beet saponins on motor activity of animals, energy, lipid and carbohydrate metabolism, osmotic resistance of red blood cells, antitoxic liver function. The 50- and 100-fold increase of the initial dose gave rise to an elevation of motor activity, lowering of the content of pre-beta-lipoproteins and increase of the amount of alpha-lipoproteins in blood serum, reduction of the osmotic resistance of red blood cells, dissociation of the processes of oxidation and phosphorylation, and decline of the energy efficacy of respiration.