Novel Approaches to Possible Targeted Therapies and Prophylaxis of Uterine Fibroids.

Uterine leiomyomas are the most common benign tumors in women of childbearing age. They may lead to problems of conception or complications during the gestational period. The methods of treatment include surgical (myomectomy and hysterectomy, embolization of arteries) and therapeutic treatment (ulipristal acetate, leuprolide acetate, cetrorelix, goserelin, mifepristone).

In Vivo Antimicrobial and Wound-Healing Activity of Resveratrol, Dihydroquercetin, and Dihydromyricetin against , and .

An increase in the spread of antibiotic-resistant opportunistic microorganisms causes serious problems in the treatment of purulent infections, burns, and trophic ulcers. We tested the antimicrobial activity in vivo of three polyphenols, Resveratrol, Dihydroquercetin (Taxifolin), and Dihydromyricetin (Ampelopsin) from Norway spruce bark to promote the elimination of and from wounds. Purulent infection was modelled on wounds in rats infected with suspensions containing 10 CFU (colony-forming unit)/mL of pathogens.

A New Recombinant Strain of Yarrowia lipolytica Producing Encapsulated Phytase from Obesumbacterium proteus.

A new recombinant strain of Yarrowia lipolytica synthesizing encapsulated highly thermostable phytase of Obesumbacterium proteus, which is recommended for use as a premix component of feed compositions in animal husbandry, was obtained.

Hepatitis E virus infection in different groups of Estonian patients and people who inject drugs.

Background: Previously we demonstrated a high prevalence of hepatitis E virus (HEV) in domestic pigs and wild boars, the main reservoir and possible source of HEV infections in humans. But so far there are no reports about spread of HEV in Estonian human population.

Objectives: The present study aimed to determine the prevalence and genotyping of HEV in different groups of the Estonian adult population.

Immunomodulating and Revascularizing Activity of Synergize with Fungicide Activity of Biogenic Peptide Cecropin P1.

Previously transgenic plants producing an antimicrobial peptide cecropin P1 (CecP1) have been reported. Now we report biological testing extracts containing CecP1 as a candidate drug for treatment of wounds infected with The drug constitutes the whole juice from leaves (not ethanol extract) sterilized with nanofiltration. A microbicide activity of CecP1 against an animal fungal pathogen in vivo was demonstrated for the first time.