Publications by authors named "E V Sukhareva"
Article Synopsis
- BDNF (Brain-derived neurotrophic factor) is vital for nerve cell growth and survival, with forms that bind to different receptors affecting brain development, especially during the neonatal period.
- Disruptions in BDNF levels during this critical time can lead to long-term behavioral issues, including increased anxiety and depression in adolescents.
- The study found that elevated levels of mature BDNF contributed to these behaviors, while mutant BDNF led to opposite transcriptional changes, suggesting a significant link between BDNF variations and the development of neurobehavioral disorders.
In this work, we have analyzed the transcriptomic changes in the brainstem of male Wistar rats 2 h after an acute stress exposure. We performed duplex-specific nuclease normalization of cDNA libraries and compared the results back-to-back for the first time. Based on our RNAseq data, we selected reference genes for RT-qPCR that are best suited for acute stress experiments.
View Article and Find Full Text PDFAmong the responses in the early stages of stroke, activation of neurodegenerative and proinflammatory processes in the hippocampus is of key importance for the development of negative post-ischemic functional consequences. However, it remains unclear, what genes are involved in these processes. The aim of this work was a comparative study of the expression of genes encoding glutamate and GABA transporters and receptors, as well as inflammation markers in the hippocampus one day after two types of middle cerebral artery occlusion (according to Koizumi et al.
View Article and Find Full Text PDFEffects of аntimicrobials on Pseudomonas aeruginosa biofilm formation.
Vavilovskii Zhurnal Genet Selektsii
August 2022
Pseudomonas aeruginosa is one of the most problematic pathogens in medical institutions, which may be due to the ability of this microorganism to exist in a biofilm, which increases its resistance to antimicrobials, as well as its prevalence and survival ability in the external environment. This work aimed to evaluate the antimicrobial susceptibility of P. aeruginosa strains in planktonic and biofilm forms.
View Article and Find Full Text PDFWe performed transcriptome analysis in the hippocampus 24 h after lipopolysaccharide (LPS) administration. We observed glial-specific genes, comprised of two-thirds of all differentially expressed genes (DEGs). We found microglial DEGs that were the most numerous in LPS group.
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